Interactions between Dryvax and Interferon gamma-1b
1 drug interaction and 7 additional warnings found for the following 2 drugs:
- Dryvax (smallpox vaccine)
- interferon gamma-1b
Drug interactions
Moderate drug interactions
Moderate:
interferon gamma-1b smallpox vaccine
Applies to: interferon gamma-1b and Dryvax (smallpox vaccine)
Generally avoid
The concomitant administration of interferon gamma with vaccines may theoretically increase the risk of an exaggerated immune response. The exact mechanism is unknown, but believed to be related to interferon gamma's immunomodulatory effects.
Management
The manufacturer recommends avoiding concomitant use with vaccines.
References (3)
- (2021) "Product Information. Imukin (interferon gamma-1b)." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 4.0
- (2021) "Product Information. Actimmune (interferon gamma-1b)." Horizon Therapeutics USA Inc
- (2022) "Product Information. Immukin (interferon gamma-1b)." Clinigen Healthcare Ltd
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
7 potential interactions Applies to: 7 conditions, including Heart Failure, Seizures, Arrhythmia, Psychosis, and Parkinsonism.
Arrhythmia
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Arrhythmia.
Hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure have been reported during interferon therapy. Therapy with interferons should be administered with caution in patients with compromised cardiac function.
Bone Marrow Depression/Low Blood Counts
Moderate:
interferon gamma-1b
Interferon gamma-1b has a moderate potential interaction with Bone Marrow Depression/Low Blood Counts.
Interferons (alfa and gamma) induce a dose-dependent, generally mild, myelosuppression. Leukopenia is the primary manifestation. Thrombocytopenia and anemia occur less frequently. Therapy with interferons (alfa and gamma) should be administered cautiously to patients with bone marrow suppression. Clinical monitoring of hematopoietic function is recommended.
Heart Failure
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Heart Failure.
Hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure have been reported during interferon therapy. Therapy with interferons should be administered with caution in patients with compromised cardiac function.
Ischemic Heart Disease
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Ischemic Heart Disease.
Hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure have been reported during interferon therapy. Therapy with interferons should be administered with caution in patients with compromised cardiac function.
Parkinsonism
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Parkinsonism.
Reversible CNS effects such as seizures, mental status changes, manic behavior or psychotic reactions, gait disturbances, and dizziness have occurred in patients receiving interferons. Therapy with interferons should be administered cautiously in patients with or predisposed to seizures, psychiatric disorders, or conditions affecting posture or gait.
Psychosis
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Psychosis.
Reversible CNS effects such as seizures, mental status changes, manic behavior or psychotic reactions, gait disturbances, and dizziness have occurred in patients receiving interferons. Therapy with interferons should be administered cautiously in patients with or predisposed to seizures, psychiatric disorders, or conditions affecting posture or gait.
Seizures
Major:
interferon gamma-1b
Interferon gamma-1b has a major potential interaction with Seizures.
Reversible CNS effects such as seizures, mental status changes, manic behavior or psychotic reactions, gait disturbances, and dizziness have occurred in patients receiving interferons. Therapy with interferons should be administered cautiously in patients with or predisposed to seizures, psychiatric disorders, or conditions affecting posture or gait.
Report options
More resources
Dryvax
A total of 392 drugs are known to interact with Dryvax.
- Dryvax is in the drug class viral vaccines.
- Dryvax is used to treat Smallpox Prophylaxis.
interferon gamma-1b
A total of 207 drugs are known to interact with interferon gamma-1b.
- Interferon gamma-1b is in the drug class interferons.
- Interferon gamma-1b is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.