Can you take Dantrolene with Flibanserin?
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- dantrolene
- flibanserin
Drug interactions
Moderate drug interactions
Moderate:
dantrolene flibanserin
Applies to: dantrolene and flibanserin
Using flibanserin together with dantrolene may increase side effects such as:
- dizziness
- drowsiness
- fatigue
- difficulty concentrating
You should avoid the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery for at least 6 hours after taking flibanserin and until you know how the medications affect you.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
flibanserin Food/Lifestyle
Applies to: flibanserin
Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to:
- dizziness
- lightheadedness
- fainting
- accidental injury
What to do: Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime.
Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment.
Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate food/lifestyle interactions
Moderate:
dantrolene Food/Lifestyle
Applies to: dantrolene
Alcohol can increase the nervous system side effects of dantrolene such as:
- dizziness
- drowsiness
- difficulty concentrating
Some people may also experience impairment in thinking and judgment.
You should avoid or limit the use of alcohol while being treated with dantrolene.
Do not use more than the recommended dose of dantrolene, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
7 potential interactions Applies to: 6 conditions, including Hypotension, Heart Disease, Syncope, Liver Disease, and Alcoholism.
Alcoholism
Major:
flibanserin
Flibanserin has a major potential interaction with Alcoholism.
The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.
Heart Disease
Moderate:
dantrolene
Dantrolene has a moderate potential interaction with Heart Disease.
Pericarditis, both with and without pleural effusion, has occasionally occurred during the long-term administration of dantrolene. It has not been reported with intravenous use in the emergency treatment of malignant hyperthermia crises. Other adverse cardiovascular effects include tachycardia, erratic blood pressure, and heart failure. Prolonged therapy with dantrolene should be administered cautiously in patients with significantly impaired cardiac function, especially if due to myocardial disease.
Hypotension
Major:
flibanserin
Flibanserin has a major potential interaction with Hypotension.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Liver Disease
Major:
dantrolene
Dantrolene has a major potential interaction with Liver Disease.
The use of oral dantrolene is contraindicated in patients with active liver disease, such as hepatitis or cirrhosis. Fatal and nonfatal liver disorders have occurred with dantrolene therapy, and baseline and periodic liver function monitoring is recommended. Dantrolene should generally be discontinued if liver function tests become significantly elevated or if symptoms compatible with hepatitis or jaundice occur.
Major:
flibanserin
Flibanserin has a major potential interaction with Liver Disease.
Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.
Pulmonary Impairment
Moderate:
dantrolene
Dantrolene has a moderate potential interaction with Pulmonary Impairment.
Dantrolene may cause respiratory depression that is possibly related to the muscle weakness produced by the drug. Pleural effusion associated with pericarditis has also occurred occasionally during the long-term administration of dantrolene. Therapy with dantrolene should be administered cautiously in patients with impaired pulmonary function, particularly that due to obstructive pulmonary disease. Patients who receive intravenous dantrolene should have vital signs monitored.
Syncope
Major:
flibanserin
Flibanserin has a major potential interaction with Syncope.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Report options
More resources
dantrolene
A total of 307 drugs are known to interact with dantrolene.
- Dantrolene is in the drug class skeletal muscle relaxants.
- Dantrolene is used to treat the following conditions:
flibanserin
A total of 517 drugs are known to interact with flibanserin.
- Flibanserin is in the drug class miscellaneous central nervous system agents.
- Flibanserin is used to treat Hypoactive Sexual Desire Disorder.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.