Can you take Clobazam with Trimethaphan camsylate?
1 drug interaction and 17 additional warnings found for the following 2 drugs:
- clobazam
- trimethaphan camsylate
Drug interactions
Moderate drug interactions
Moderate:
trimethaphan camsylate cloBAZam
Applies to: trimethaphan camsylate and clobazam
CloBAZam and trimethaphan camsylate may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted. Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
cloBAZam Food/Lifestyle
Applies to: clobazam
Alcohol can increase the nervous system side effects of cloBAZam such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloBAZam. Do not use more than the recommended dose of cloBAZam, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
trimethaphan camsylate Alcohol (Ethanol)
Applies to: trimethaphan camsylate
Ethanol and trimethaphan camsylate may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted. Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
15 potential interactions Applies to: 14 conditions, including Depression, Allergies, Anemia, Psychosis, and Diabetes Mellitus.
Acute Alcohol Intoxication
Major:
clobazam
cloBAZam has a major potential interaction with Acute Alcohol Intoxication.
The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
Adrenal Insufficiency
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Adrenal Insufficiency.
The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.
Allergies
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Allergies.
Trimethaphan causes histamine release. A histamine-like reaction has been observed along the vein used for drug administration. Although it is considered a weak histamine liberator, therapy with trimethaphan should be administered cautiously in patients with allergies.
Anemia
Major:
trimethaphan camsylate
Trimethaphan camsylate has a major potential interaction with Anemia.
The use of trimethaphan is contraindicated in patients with anemia, hypovolemia, shock, asphyxia, respiratory insufficiency or other conditions in which the vasodilating and hypotensive effects of trimethaphan may pose undue risk.
Asphyxia
Major:
trimethaphan camsylate
Trimethaphan camsylate has a major potential interaction with Asphyxia.
The use of trimethaphan is contraindicated in patients with anemia, hypovolemia, shock, asphyxia, respiratory insufficiency or other conditions in which the vasodilating and hypotensive effects of trimethaphan may pose undue risk.
Cardiovascular Conditions and Disorders
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Cardiovascular Conditions and Disorders.
The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.
Dehydration
Major:
trimethaphan camsylate
Trimethaphan camsylate has a major potential interaction with Dehydration.
The use of trimethaphan is contraindicated in patients with anemia, hypovolemia, shock, asphyxia, respiratory insufficiency or other conditions in which the vasodilating and hypotensive effects of trimethaphan may pose undue risk.
Depression
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Depression.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Diabetes Mellitus
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Diabetes Mellitus.
The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.
Drug Dependence
Major:
clobazam
cloBAZam has a major potential interaction with Drug Dependence.
Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
Liver Disease
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Liver Disease.
The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.
Psychosis
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Psychosis.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Renal Dysfunction
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Renal Dysfunction.
Benzodiazepines are excreted by the kidneys and should be used with caution in patients with impaired renal function and end-stage kidney disease.
Moderate:
trimethaphan camsylate
Trimethaphan camsylate has a moderate potential interaction with Renal Dysfunction.
The use of trimethaphan may reduce coronary and cerebral blood flow. Therapy with trimethaphan should be administered cautiously in patients with arteriosclerosis, cardiac disease, hepatic or renal disease, degenerative CNS disease, Addison's disease, and diabetes. Monitoring heart rate and blood pressure at frequent intervals is recommended.
Shock
Major:
trimethaphan camsylate
Trimethaphan camsylate has a major potential interaction with Shock.
The use of trimethaphan is contraindicated in patients with anemia, hypovolemia, shock, asphyxia, respiratory insufficiency or other conditions in which the vasodilating and hypotensive effects of trimethaphan may pose undue risk.
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clobazam
A total of 537 drugs are known to interact with clobazam.
- Clobazam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
- Clobazam is used to treat the following conditions:
trimethaphan camsylate
A total of 212 drugs are known to interact with trimethaphan camsylate.
- Trimethaphan camsylate is in the drug class agents for hypertensive emergencies.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.