Can you take Clobazam with Phenoxybenzamine?
1 drug interaction and 12 additional warnings found for the following 2 drugs:
- clobazam
- phenoxybenzamine
Drug interactions
Moderate drug interactions
Moderate:
phenoxybenzamine cloBAZam
Applies to: phenoxybenzamine and clobazam
CloBAZam and phenoxybenzamine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted. Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
cloBAZam Food/Lifestyle
Applies to: clobazam
Alcohol can increase the nervous system side effects of cloBAZam such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloBAZam. Do not use more than the recommended dose of cloBAZam, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
phenoxybenzamine Alcohol (Ethanol)
Applies to: phenoxybenzamine
Ethanol and phenoxybenzamine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted. Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
10 potential interactions Applies to: 9 conditions, including Depression, Heart Failure, Psychosis, Drug Dependence, and Ischemic Heart Disease.
Acute Alcohol Intoxication
Major:
clobazam
cloBAZam has a major potential interaction with Acute Alcohol Intoxication.
The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
Cerebral Vascular Disorder
Major:
phenoxybenzamine
Phenoxybenzamine has a major potential interaction with Cerebral Vascular Disorder.
The use of phenoxybenzamine is contraindicated when a decrease in blood pressure may be undesirable, such as in patients with marked cerebrovascular or coronary insufficiency in whom ischemia may be aggravated. Also, phenoxybenzamine- induced reflex tachycardia can precipitate frank congestive heart failure (CHF) and angina in patients with compensated CHF or coronary artery disease. Phenoxybenzamine should be used with caution under such circumstances.
Depression
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Depression.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Drug Dependence
Major:
clobazam
cloBAZam has a major potential interaction with Drug Dependence.
Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
Heart Failure
Major:
phenoxybenzamine
Phenoxybenzamine has a major potential interaction with Heart Failure.
The use of phenoxybenzamine is contraindicated when a decrease in blood pressure may be undesirable, such as in patients with marked cerebrovascular or coronary insufficiency in whom ischemia may be aggravated. Also, phenoxybenzamine- induced reflex tachycardia can precipitate frank congestive heart failure (CHF) and angina in patients with compensated CHF or coronary artery disease. Phenoxybenzamine should be used with caution under such circumstances.
Ischemic Heart Disease
Major:
phenoxybenzamine
Phenoxybenzamine has a major potential interaction with Ischemic Heart Disease.
The use of phenoxybenzamine is contraindicated when a decrease in blood pressure may be undesirable, such as in patients with marked cerebrovascular or coronary insufficiency in whom ischemia may be aggravated. Also, phenoxybenzamine- induced reflex tachycardia can precipitate frank congestive heart failure (CHF) and angina in patients with compensated CHF or coronary artery disease. Phenoxybenzamine should be used with caution under such circumstances.
Pleuropulmonary Infection
Moderate:
phenoxybenzamine
Phenoxybenzamine has a moderate potential interaction with Pleuropulmonary Infection.
The adrenergic blocking effect of phenoxybenzamine may aggravate the symptoms of respiratory infections. Caution is recommended when treating patients with respiratory infections.
Psychosis
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Psychosis.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Renal Dysfunction
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Renal Dysfunction.
Benzodiazepines are excreted by the kidneys and should be used with caution in patients with impaired renal function and end-stage kidney disease.
Moderate:
phenoxybenzamine
Phenoxybenzamine has a moderate potential interaction with Renal Dysfunction.
Phenoxybenzamine should be administered with caution in patients with marked renal damage.
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More resources
clobazam
A total of 537 drugs are known to interact with clobazam.
- Clobazam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
- Clobazam is used to treat the following conditions:
phenoxybenzamine
A total of 237 drugs are known to interact with phenoxybenzamine.
- Phenoxybenzamine is in the drug class miscellaneous cardiovascular agents.
- Phenoxybenzamine is used to treat Pheochromocytoma.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.