Can you take Clobazam with Daridorexant?
1 drug interaction and 13 additional warnings found for the following 2 drugs:
- clobazam
- daridorexant
Drug interactions
Moderate drug interactions
Moderate:
cloBAZam daridorexant
Applies to: clobazam and daridorexant
Using cloBAZam together with daridorexant may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
cloBAZam Food/Lifestyle
Applies to: clobazam
Alcohol can increase the nervous system side effects of cloBAZam such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloBAZam. Do not use more than the recommended dose of cloBAZam, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
daridorexant Food/Lifestyle
Applies to: daridorexant
Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with daridorexant unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of daridorexant. This may increase the risk of side effects such as somnolence, fatigue, abnormal sleep behaviors, worsening of depression or suicidal thoughts, or headache. You should avoid the use of alcohol while being treated with daridorexant. Alcohol can increase the nervous system side effects of daridorexant such as dizziness, drowsiness, and reduced coordination. Some people may also experience complex sleep behaviors such as sleepwalking, sleep driving, preparing and eating food or doing other activities while not fully awake that you may not remember the next morning. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
11 potential interactions Applies to: 9 conditions, including Depression, Narcolepsy, Psychosis, Liver Disease, and Drug Dependence.
Acute Alcohol Intoxication
Major:
clobazam
cloBAZam has a major potential interaction with Acute Alcohol Intoxication.
The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
Alcoholism
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Alcoholism.
Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.
Depression
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Depression.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Depression.
Daridorexant can worsen depression and suicidal thoughts and actions and should be used with caution in patients with depression. These patients should be monitored closely and any preventive measures should be taken.
Drug Dependence
Major:
clobazam
cloBAZam has a major potential interaction with Drug Dependence.
Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Drug Dependence.
Patients with a history of abuse or addiction to alcohol or other substances may be at increased risk for abuse of or addiction to daridorexant and should be monitored closely.
Liver Disease
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Liver Disease.
Daridorexant is not recommended in patients with severe hepatic dysfunction. The maximum recommended dosage in patients with moderate hepatic dysfunction is 25 mg once per night.
Narcolepsy
Major:
daridorexant
Daridorexant has a major potential interaction with Narcolepsy.
Daridorexant is contraindicated in patients with narcolepsy.
Psychosis
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Psychosis.
Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Pulmonary Impairment
Moderate:
daridorexant
Daridorexant has a moderate potential interaction with Pulmonary Impairment.
Daridorexant is a respiratory depressant and should be used with caution if prescribed to patients with impaired respiratory function. This drug has not been studied in patients with moderate to severe sleep apnea requiring CPAP or in patients with severe chronic obstructive pulmonary disease (COPD).
Renal Dysfunction
Moderate:
clobazam
cloBAZam has a moderate potential interaction with Renal Dysfunction.
Benzodiazepines are excreted by the kidneys and should be used with caution in patients with impaired renal function and end-stage kidney disease.
Report options
More resources
clobazam
A total of 537 drugs are known to interact with clobazam.
- Clobazam is in the following drug classes: benzodiazepine anticonvulsants, benzodiazepines.
- Clobazam is used to treat the following conditions:
daridorexant
A total of 778 drugs are known to interact with daridorexant.
- Daridorexant is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Daridorexant is used to treat Insomnia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.