Can you take Cisapride with Fematrol?
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- cisapride
- Fematrol (bisacodyl)
Drug interactions
Moderate drug interactions
Moderate:
bisacodyl cisapride
Applies to: Fematrol (bisacodyl) and cisapride
Cisapride can cause an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. The risk is increased if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances, such as low blood levels of magnesium or potassium. These electrolyte disturbances can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect, such as bisacodyl. Do not exceed the dose and duration recommended on the product label or prescribed by your doctor. You should seek immediate medical attention if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether taken together or separately. In addition, you should let your doctor know if you experience signs and symptoms of low magnesium or potassium blood level such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
cisapride Food/Lifestyle
Applies to: cisapride
Cisapride is no longer on the market in the US. Do not take cisapride with any other medication, food, or beverage.
**Cisapride (Propulsid) is no longer marketed in the United States. You should only be taking cisapride if you are obtaining the medication from your doctor though a Limited Access Program developed jointly by the manufacturer and the FDA.**
Moderate food/lifestyle interactions
Moderate:
bisacodyl multivitamins with minerals
Applies to: Fematrol (bisacodyl)
Chronic use of bisacodyl may reduce your body's ability to absorb certain vitamins (A, D, E, and K) and minerals like calcium. To reduce the risk of diminished absorption of multivitamins with minerals, it is best to use bisacodyl only occasionally or for short periods. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
8 potential interactions Applies to: 7 conditions, including Inflammatory Bowel Disease, Bleeding Disorder, Cardiovascular Conditions and Disorders, Gastrointestinal Perforation, and Gastrointestinal Hemorrhage.
Appendicitis
Major:
Fematrol
The bisacodyl in Fematrol has a major potential interaction with Appendicitis.
The use of stimulant laxatives is contraindicated in patients with or who may have acute surgical abdomen or appendicitis. These patients may be candidates for emergency surgery. Stimulant laxatives should also not be administered to patients with abdominal pain, particularly if the cause has not been determined.
Bleeding Disorder
Major:
Fematrol
The bisacodyl in Fematrol has a major potential interaction with Bleeding Disorder.
The use of stimulant laxatives is contraindicated in patients with anal or rectal fissures. These preparations may cause irritation, burning sensation, and proctitis.
Cardiovascular Conditions and Disorders
Major:
cisapride
Cisapride has a major potential interaction with Cardiovascular Conditions and Disorders.
The use of cisapride is contraindicated in patients with cardiac disease. Serious cardiac arrhythmias, including ventricular arrhythmias and torsades de pointes associated with QT prolongation have been rarely associated with the use of cisapride, especially when taken in conjunction with other medications known to prolong the QT interval.
Gastrointestinal Hemorrhage
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Hemorrhage.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Gastrointestinal Obstruction
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Obstruction.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Major:
Fematrol
The bisacodyl in Fematrol has a major potential interaction with Gastrointestinal Obstruction.
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
Gastrointestinal Perforation
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Perforation.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Inflammatory Bowel Disease
Major:
Fematrol
The bisacodyl in Fematrol has a major potential interaction with Inflammatory Bowel Disease.
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
Report options
More resources
cisapride
A total of 417 drugs are known to interact with cisapride.
- Cisapride is in the drug class GI stimulants.
- Cisapride is used to treat the following conditions:
Fematrol
A total of 276 drugs are known to interact with Fematrol.
- Fematrol is in the drug class laxatives.
- Fematrol is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.