Can you take Cilostazol with Plasminogen, human?
1 drug interaction and 6 additional warnings found for the following 2 drugs:
- cilostazol
- plasminogen, human
Drug interactions
Major drug interactions
Major:
cilostazol plasminogen, human
Applies to: cilostazol and plasminogen, human
Using plasminogen, human together with cilostazol may increase the risk of bleeding.
Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications.
You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as:
- dizziness
- lightheadedness
- red or black, tarry stools
- coughing up or vomiting fresh or dried blood that looks like coffee grounds
- severe headache
- weakness
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
cilostazol Food/Lifestyle
Applies to: cilostazol
Take cilostazol on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. Food may reduce the absorption of cilostazol. Taking cilostazol on an empty stomach will make it easier for your body to absorb the medication.
If you are receiving therapy with cilostazol you should avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of cilostazol in your body and lead to dangerous side effects.
You may experience:
- headache
- dizziness
- chest pain
- feeling short of breath
- swelling of your ankles or feet
Call your doctor at once if you have any of these symptoms.
Disease interactions
5 potential interactions Applies to: 5 conditions, including Heart Failure, Liver Disease, Bleeding Disorder, Ischemic Heart Disease, and Coagulation Defects and Disorders.
Bleeding Disorder
Major:
cilostazol
Cilostazol has a major potential interaction with Bleeding Disorder.
Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.
Coagulation Defects and Disorders
Major:
cilostazol
Cilostazol has a major potential interaction with Coagulation Defects and Disorders.
Cilostazol inhibits platelet aggregation in a reversible manner. Cilostazol has not been studied in patients with hemostatic disorders or active pathologic bleeding. Avoid use of cilostazol tablets in these patients.
Heart Failure
Major:
cilostazol
Cilostazol has a major potential interaction with Heart Failure.
The use of cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III- IV heart failure.
Ischemic Heart Disease
Moderate:
cilostazol
Cilostazol has a moderate potential interaction with Ischemic Heart Disease.
Cilostazol may induce tachycardia, palpitation, tachyarrhythmia or hypotension. The increase in heart rate associated with cilostazol is approximately 5 to 7 bpm. Patients with a history of ischemic heart disease may be at risk for exacerbations of angina pectoris or myocardial infarction. Caution is advised.
Liver Disease
Moderate:
cilostazol
Cilostazol has a moderate potential interaction with Liver Disease.
No cilostazol dose adjustment is required in patients with mild hepatic impairment. Patients with moderate or severe hepatic impairment have not been studied in clinical trials and dosing recommendations cannot be provided. Caution is advised if used in these patients.
Report options
More resources
cilostazol
A total of 502 drugs are known to interact with cilostazol.
- Cilostazol is in the following drug classes: miscellaneous cardiovascular agents, platelet aggregation inhibitors.
- Cilostazol is used to treat Intermittent Claudication.
plasminogen, human
A total of 77 drugs are known to interact with plasminogen, human.
- Plasminogen, human is in the drug class miscellaneous uncategorized agents.
- Plasminogen, human is used to treat Hypoplasminogenemia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.