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Drug Interactions between calcifediol and sucroferric oxyhydroxide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

calcifediol sucroferric oxyhydroxide

Applies to: calcifediol and sucroferric oxyhydroxide

GENERALLY AVOID: Coadministration with sucroferric oxyhydroxide may reduce the oral bioavailability of vitamin D analogs. The proposed mechanism involves nonspecific adsorption to the ferric ion component of sucroferric oxyhydroxide, resulting in an insoluble complex that is poorly absorbed from the gastrointestinal tract. According to the product labeling for sucroferric oxyhydroxide, an in vitro interaction with paricalcitol was observed when studied in aqueous solutions that mimic the physico-chemical conditions of the gastrointestinal tract.

MANAGEMENT: Oral formulations of vitamin D analogs should not be prescribed with sucroferric oxyhydroxide.

References

  1. "Product Information. Velphoro (sucroferric oxyhydroxide)." Fresenius Medical Care North America (2014):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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