Drug Interactions between caffeine and tacrolimus
This report displays the potential drug interactions for the following 2 drugs:
- caffeine
- tacrolimus
Interactions between your drugs
No interactions were found between caffeine and tacrolimus. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
caffeine
A total of 109 drugs are known to interact with caffeine.
- Caffeine is in the drug class CNS stimulants.
-
Caffeine is used to treat the following conditions:
- Apnea of Prematurity
- Asthma (off-label)
- Drowsiness
tacrolimus
A total of 867 drugs are known to interact with tacrolimus.
- Tacrolimus is in the drug class calcineurin inhibitors.
-
Tacrolimus is used to treat the following conditions:
- Crohn's Disease (off-label)
- Graft Versus Host Disease (off-label)
- Nephrotic Syndrome (off-label)
- Organ Transplant, Rejection Prophylaxis
- Organ Transplant, Rejection Reversal
Drug and food interactions
tacrolimus food
Applies to: tacrolimus
ADJUST DOSING INTERVAL: Consumption of food has led to a 27% decrease in the bioavailability of orally administered tacrolimus.
MANAGEMENT: Tacrolimus should be administered at least one hour before or two hours after meals.
GENERALLY AVOID: Grapefruit juice has been reported to increase tacrolimus trough concentrations. Data are limited, but inhibition of the CYP450 enzyme system appears to be involved.
MANAGEMENT: The clinician may want to recommend that the patient avoid ingesting large amounts of grapefruit juice while taking tacrolimus.
References (2)
- (2001) "Product Information. Prograf (tacrolimus)." Fujisawa
- Hooks MA (1994) "Tacrolimus, a new immunosuppressant--a review of the literature." Ann Pharmacother, 28, p. 501-11
caffeine food
Applies to: caffeine
The effect of grapefruit juice on the pharmacologic activity of caffeine is controversial. One report suggests that grapefruit juice increases the effect of caffeine. The proposed mechanism is inhibition of cytochrome P-450 metabolism of caffeine. However, a well-conducted pharmacokinetic/pharmacodynamic study did not demonstrate this effect. The clinical significance of this potential interaction is unknown.
References (2)
- (1995) "Grapefruit juice interactions with drugs." Med Lett Drugs Ther, 37, p. 73-4
- Maish WA, Hampton EM, Whitsett TL, Shepard JD, Lovallo WR (1996) "Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics." Pharmacotherapy, 16, p. 1046-52
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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