Drug Interactions between Bosulif and folic acid
This report displays the potential drug interactions for the following 2 drugs:
- Bosulif (bosutinib)
- folic acid
Interactions between your drugs
No interactions were found between Bosulif and folic acid. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Bosulif
A total of 533 drugs are known to interact with Bosulif.
- Bosulif is in the drug class BCR-ABL tyrosine kinase inhibitors.
- Bosulif is used to treat Chronic Myelogenous Leukemia.
folic acid
A total of 35 drugs are known to interact with folic acid.
- Folic acid is in the drug class vitamins.
- Folic acid is used to treat the following conditions:
Drug and food interactions
folic acid food
Applies to: folic acid
MONITOR: Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
MANAGEMENT: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
- Cerner Multum, Inc "ANVISA Bulário Eletrônico." O 0 (2015):
- "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC (2017):
bosutinib food
Applies to: Bosulif (bosutinib)
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of bosutinib. When given with a high-fat meal, bosutinib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.8- and 1.7-fold, respectively.
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of bosutinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Bosutinib should be administered with a meal. The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided.
References
- "Product Information. Bosulif (bosutinib)." Pfizer U.S. Pharmaceuticals Group (2012):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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