Drug Interactions between Augmentin and Multaq
This report displays the potential drug interactions for the following 2 drugs:
- Augmentin (amoxicillin/clavulanate)
- Multaq (dronedarone)
Interactions between your drugs
No interactions were found between Augmentin and Multaq. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Augmentin
A total of 70 drugs are known to interact with Augmentin.
- Augmentin is in the drug class beta-lactamase inhibitors.
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Augmentin is used to treat the following conditions:
- Aspiration Pneumonia
- Bacterial Infection
- Bronchiectasis
- Bronchitis
- Febrile Neutropenia
- Kidney Infections
- Melioidosis
- Otitis Media
- Pneumonia
- Sinusitis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Small Bowel Bacterial Overgrowth
- Strep Throat
- Upper Respiratory Tract Infection
- Urinary Tract Infection
Multaq
A total of 656 drugs are known to interact with Multaq.
- Multaq is in the drug class group III antiarrhythmics.
- Multaq is used to treat the following conditions:
Drug and food interactions
dronedarone food
Applies to: Multaq (dronedarone)
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of dronedarone. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. According to the product labeling, administration with grapefruit juice resulted in a 2.5-fold increase in dronedarone peak plasma concentration and a 3-fold increase in systemic exposure. Because dronedarone is associated with concentration-dependent prolongation of the QT interval, increased levels may potentiate the risk of ventricular arrhythmias such as torsade de pointes and sudden death.
ADJUST DOSING INTERVAL: Food increases the oral bioavailability of dronedarone. The mechanism of interaction is unknown. According to the product labeling, the absolute bioavailability of dronedarone increases from about 4% when administered in the fasted state to approximately 15% when administered with a high-fat meal.
MANAGEMENT: Patients treated with dronedarone should avoid consumption of grapefruit, grapefruit juice, and any supplement containing grapefruit extract. Dronedarone should be taken twice daily with the morning and evening meals.
References
- "Product Information. Multaq (dronedarone)." sanofi-aventis (2009):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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