Drug Interactions between Ambien and cinacalcet
This report displays the potential drug interactions for the following 2 drugs:
- Ambien (zolpidem)
- cinacalcet
Interactions between your drugs
No interactions were found between Ambien and cinacalcet. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Ambien
A total of 463 drugs are known to interact with Ambien.
- Ambien is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Ambien is used to treat Insomnia.
cinacalcet
A total of 142 drugs are known to interact with cinacalcet.
- Cinacalcet is in the drug class calcimimetics.
- Cinacalcet is used to treat the following conditions:
Drug and food interactions
zolpidem food
Applies to: Ambien (zolpidem)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of zolpidem. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
ADJUST DOSING INTERVAL: Administration of zolpidem with food may delay the onset of hypnotic effects. In 30 healthy subjects, administration of zolpidem 20 minutes after a meal resulted in decreased mean peak plasma drug concentration (Cmax) and area under the concentration-time curve (AUC) by 25% and 15%, respectively, compared to fasting. The time to reach peak plasma drug concentration (Tmax) was prolonged by 60%, from 1.4 to 2.2 hours.
MANAGEMENT: Patients receiving zolpidem should be advised to avoid the consumption of alcohol. For faster sleep onset, zolpidem should not be administered with or immediately after a meal.
References
- "Product Information. Ambien (zolpidem)." sanofi-aventis PROD (2001):
- Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG "Drug-food interactions in clinical practice." J Fam Pract 40 (1995): 376-84
cinacalcet food
Applies to: cinacalcet
ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of cinacalcet. According to the product labeling for cinacalcet, administration with a high-fat meal increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of cinacalcet by 82% and 68%, respectively, compared to administration in the fasting state. The Cmax and AUC were increased 65% and 50%, respectively, when cinacalcet was administered with a low-fat meal compared to fasting.
MANAGEMENT: To ensure maximal oral absorption, cinacalcet should be administered with or immediately after a meal. The tablets should be taken whole and not divided or crushed.
References
- "Product Information. Sensipar (cinacalcet)." Amgen USA (2004):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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