Drug Interactions between acyclovir and ganciclovir
This report displays the potential drug interactions for the following 2 drugs:
- acyclovir
- ganciclovir
Interactions between your drugs
No interactions were found between acyclovir and ganciclovir. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
acyclovir
A total of 67 drugs are known to interact with acyclovir.
- Acyclovir is in the drug class purine nucleosides.
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Acyclovir is used to treat the following conditions:
- Cold Sores
- Herpes Simplex
- Herpes Simplex - Congenital
- Herpes Simplex Encephalitis
- Herpes Simplex, Mucocutaneous/Immunocompetent Host
- Herpes Simplex, Mucocutaneous/Immunocompromised Host
- Herpes Simplex, Suppression
- Herpes Zoster
- Infectious Mononucleosis (off-label)
- Mononucleosis (off-label)
- Ramsay Hunt Syndrome
- Varicella-Zoster
ganciclovir
A total of 240 drugs are known to interact with ganciclovir.
- Ganciclovir is in the drug class purine nucleosides.
- Ganciclovir is used to treat the following conditions:
Drug and food interactions
ganciclovir food
Applies to: ganciclovir
ADJUST DOSING INTERVAL: Food delays but enhances the oral absorption and bioavailability of ganciclovir capsules, possibly due to prolongation of gastrointestinal transit time. In 20 HIV- and CMV-seropositive subjects, ganciclovir dosing (1000 mg every 8 hours) following a standardized high-fat breakfast increased the mean steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ganciclovir by an average of 15% and 22%, respectively, compared to dosing after an overnight fast. The time to reach peak plasma concentration (Tmax) was prolonged from 1.8 to 3 hours. In another study of 15 such patients, administration of ganciclovir (2000 mg) within 30 minutes following a high-fat breakfast increased the Cmax and AUC an average of 111% and 114%, respectively, compared to administration in the fasting state (i.e. at least 1 hour before or 2 hours after a meal or snack). Over the total day of dosing (2000 mg orally three times a day), there was a mean increase of 48% and 97% in Cmax and AUC, respectively, and a 36% decrease in half-life during administration with meals.
MANAGEMENT: To ensure maximal oral absorption, oral ganciclovir should be administered with or immediately after a meal.
References
- "Product Information. Cytovene (ganciclovir)." Genentech PROD (2002):
- Lavelle J, Follansbee S, Trapnell CB, Buhles WC, Griffy KG, Jung D, Dorr A, Conner J "Effect of food on the relative bioavailability of oral ganciclovir." J Clin Pharmacol 36 (1996): 238-41
- Jung D, Griffy K, Dorr A "Effect of food on high-dose oral ganciclovir disposition in HIV-positive subjects." J Clin Pharmacol 39 (1999): 161-5
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Acyclovir-like antivirals
Therapeutic duplication
The recommended maximum number of medicines in the 'acyclovir-like antivirals' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'acyclovir-like antivirals' category:
- acyclovir
- ganciclovir
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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