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Drug Interactions between Activase and defibrotide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

alteplase defibrotide

Applies to: Activase (alteplase) and defibrotide

CONTRAINDICATED: Coadministration of defibrotide with fibrinolytic therapy may increase the risk of bleeding. In vitro, defibrotide increased the activity of fibrinolytic enzymes. In a mouse model of thromboembolism, recombinant tissue plasminogen activator (t-PA) potentiated the antithrombotic effect of defibrotide when given intravenously.

MANAGEMENT: Concomitant use of defibrotide with fibrinolytic therapy is considered contraindicated. Fibrinolytic agents should be discontinued prior to initiation of defibrotide. Preferably, defibrotide administration should be delayed until the effects of fibrinolytic therapy have subsided. Patients should be monitored for signs of bleeding during defibrotide therapy. If bleeding develops, defibrotide should be discontinued and treatment/supportive care provided until the bleeding stops.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. "Product Information. Defitelio (defibrotide)." Jazz Pharmaceuticals (2016):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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