Typhoid Vaccine, Live Dosage

Usual Adult Dose for Typhoid Prophylaxis

1 capsule orally, on days 1, 3, 5, and 7, 1 hour before a meal, with cold or lukewarm fluids

Comments:
-The course should be completed at least 1 week before potential exposure to S. typhi.
-Efficacy has been shown to persist for at least 5 years
-Routine immunization is not recommended.
-Immunization is recommended for travelers to areas with a recognized risk, persons with close exposure to a S. typhi carrier, and laboratory workers who work frequently with S. typhi.

Usual Pediatric Dose for Typhoid Prophylaxis

6 years and older:
1 capsule orally, on days 1, 3, 5, and 7, 1 hour before a meal, with cold or lukewarm fluids

Comments:
-The course should be completed at least 1 week before potential exposure to S. typhi.
-Efficacy has been shown to persist for at least 5 years
-Routine immunization is not recommended.
-Immunization is recommended for travelers to areas with a recognized risk, persons with close exposure to a S. typhi carrier, and laboratory workers who work frequently with S. typhi.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

-An optimum booster schedule has not been determined.
-The recommended re-immunization dose consisting of 4 capsules taken on alternate days be given every 5 years under conditions of repeated or continued exposure to typhoid fever.

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

To report suspected adverse reactions, contact Crucell Vaccines at http://www.crucell.com.us or the Vaccine Adverse Event Reporting System (VAERS) at http://www.fda.gov/vaers .

Dialysis

No adjustment recommended

Other Comments

Administration advice:
-Take with cold or lukewarm drink, approximately 1 hour before food.
-Do not chew.
-Swallow as soon as possible after placing in mouth.

Storage requirements:
-Keep refrigerated at all times.

Patient advice:
-It is essential that all 4 doses be taken at the prescribed alternate day schedule to obtain maximum protection.
-Not all people will be protected from typhoid fever; take precautions to avoid exposure.