Generic name: oxytocin
Dosage form: Injection, USP
Drug class: Uterotonic agents
Medically reviewed by Drugs.com. Last updated on Jul 8, 2022.
Dosage of oxytocin is determined by uterine response. The following dosage information is based upon the various regimens and indications in general use. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, wherever solution and container permit.
A. Induction of Stimulation of Labor
Intravenous infusion (drip method) is the only acceptable method of administration for the induction or stimulation of labor.
Accurate control of the rate of infusion flow is essential. An infusion pump or other such device and frequent monitoring of strength of contractions and fetal heart rate are necessary for the safe administration of oxytocin for the induction or stimulation of labor. If uterine contractions become too powerful, the infusion can be abruptly stopped, and oxytocin stimulation of the uterine musculature will soon wane.
- An intravenous infusion of non-oxytocin containing solution should be started. Physiologic electrolyte solution should be used except under unusual circumstances.
- To prepare the usual solution for infusion, the contents of one 1-mL ampul are combined aseptically with 1,000 mL of non-hydrating diluent. The combined solution, rotated in the infusion bottle to insure thorough mixing, contains 10 mU/mL. Add the container with dilute oxytocin solution to the system through use of a constant infusion pump or other such device, to control accurately the rate of infusion.
- The initial dose should be no more than 1-2 mU/minute. The dose may be gradually increased in increments of no more than 1-2 mU/minute, until a contraction pattern has been established which is similar to norma1 labor.
- The fetal heart rate, resting uterine tone, and the frequency, duration, and force of contractions should be monitored.
- The oxytocin infusion should be discontinued immediately in the event of uterine hyperactivity or fetal distress. Oxygen should be administered to the mother. The mother and the fetus must be evaluated by the responsible physician.
B. Control of Postpartum Uterine Bleeding
- Intravenous Infusion (Drip Method): To control postpartum bleeding, 10-40 units of oxytocin may be added to 1,000 mL of a non-hydrating diluent and run at a rate necessary to control uterine atony.
- Intramuscular Administration: 1 mL (10 units) of oxytocin can be given after delivery of the placenta.
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