Spikevax Dosage
Generic name: CX-046684 50ug in 0.5mL
Dosage form: injection, suspension
Drug class: Viral vaccines
Medically reviewed by Drugs.com. Last updated on Jul 10, 2025.
For intramuscular use.
2.1 Preparation for Administration
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- Verify that the label on the pre-filled syringe states 2024-2025 Formula.
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- If pre-filled syringes of SPIKEVAX are frozen, thaw before use following the instructions below.
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Thaw in Refrigerator 2°C to 8°C (36°F to 46°F) |
Thaw at Room Temperature 15°C to 25°C (59°F to 77°F) |
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Carton of 10 syringes |
Thaw for 2 hours and |
Thaw for 1 hour and |
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Carton of 2 syringes |
Thaw for 1 hour and |
Thaw for 40 minutes |
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One syringe (removed from carton) |
Thaw for 1 hour and |
Thaw for 40 minutes |
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- After thawing, do not refreeze.
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- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
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- SPIKEVAX is a white to off-white suspension. It may contain white or translucent product-related particulates. Do not administer if vaccine is discolored or contains other particulate matter.
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- Do not shake.
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- With tip cap upright, remove tip cap by twisting counterclockwise until tip cap releases. Remove tip cap in a slow, steady motion. Avoid pulling tip cap while twisting.
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- Attach the needle by twisting in a clockwise direction until the needle fits securely on the syringe.
2.3 Dosing and Schedule
| a Previous dose refers to a dose of any authorized Moderna COVID-19 Vaccine. b Not previously vaccinated with any COVID-19 vaccine. c Individuals turning from 23 months to 2 years of age during the vaccination series should receive both doses with SPIKEVAX. |
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Number of Previous Doses of Moderna COVID-19 Vaccine(s)a |
SPIKEVAX Dosing Regimen, Dose and Schedule |
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0b |
2 doses,c 0.25 mL each Dose 1: month 0 Dose 2: month 1 |
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1 |
Single dose, 0.25 mL One month after receipt of a previous dose of Moderna COVID-19 vaccinea |
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≥2 |
Single dose, 0.25 mL ≥2 months after receipt of the last previous dose of Moderna COVID-19 vaccinea |
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Age |
SPIKEVAX Dosing Regimen, Dose and Schedule |
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2 years through 11 years |
Single dose, 0.25 mL |
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12 years and older |
Single dose, 0.5 mL |
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If previously vaccinated with any COVID-19 vaccine, administer the dose ≥2 months after the last dose of COVID-19 vaccine |
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Frequently asked questions
More about Spikevax (COVID-19 mRNA (Moderna) vaccine)
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- During pregnancy
- Drug class: viral vaccines
Patient resources
Professional resources
- Spikevax prescribing information
- COVID-19 Vaccine, mRNA (Moderna) (2024-2025 Formula) (AHFS Monograph)
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Further information
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