Medically reviewed by Drugs.com. Last updated on Oct 8, 2020.
Generic name: Ripretinib 50mg
Dosage form: tablet
The recommended dosage of QINLOCK is 150 mg orally once daily with or without food until disease progression or unacceptable toxicity.
Instruct patients to swallow tablets whole.
Advise patients to take QINLOCK at the same time each day.
Advise patients to take a missed dose if less than 8 hours have passed since the missed scheduled dose.
Advise patients not to take an additional dose if vomiting occurs after taking QINLOCK and to continue with their next scheduled dose.
Dosage Modifications for Adverse Reactions
The recommended dose reduction for adverse reactions is:
- QINLOCK 100 mg orally once daily.
Permanently discontinue QINLOCK in patients who are unable to tolerate 100 mg orally once daily.
The recommended dosage modifications of QINLOCK for adverse reactions are provided in Table 1.
|Adverse Reaction||Severitya||QINLOCK Dosage Modifications|
a Graded per National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03 (NCI CTCAE v4.03).
|Palmar-Plantar Erythrodysesthesia Syndrome (PPES) [see Warnings and Precautions (5.1)]||Grade 2||
|Hypertension [see Warnings and Precautions (5.3)]||Grade 3||
||Permanently discontinue QINLOCK.|
|Left Ventricular Systolic Dysfunction [see Warnings and Precautions (5.4)]||Grade 3 or 4||Permanently discontinue QINLOCK.|
|Arthralgia or Myalgia [see Adverse Reactions (6.1)]||Grade 2||
|Other Adverse Reactions [see Adverse Reactions (6.1)]||Grade 3 or 4||
More about Qinlock (ripretinib)
- Side Effects
- During Pregnancy
- Imprints, Shape & Color Data
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: multikinase inhibitors
- FDA Approval History
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