Olezarsen Dosage

Medically reviewed by Drugs.com. Last updated on Feb 3, 2025.

Usual Adult Dose for Chylomicronemia Syndrome

80 mg subcutaneously once a month

Comments:

• It is advised to maintain a low-fat diet (Up to 20 g fat per day) while using this drug.
• Before starting, patients and/or caregivers should be instructed on the correct preparation and administration of this drug.

Use: As an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome

Renal Dose Adjustments

Mild to moderate renal dysfunction (estimated GFR [eGFR] 30 to less than 90 mL/min): No adjustment recommended
Severe renal dysfunction or ESRD: Data not available

Liver Dose Adjustments

Mild liver dysfunction: No adjustment recommended
Moderate to severe liver dysfunction: Data not available

Precautions

CONTRAINDICATIONS:

• History of serious hypersensitivity to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Allow single-dose autoinjector to warm to room temperature; remove from refrigerator 30 minutes before injection. Do not use other warming methods.
• Visually inspect for particulate matter before administration. Do not use if cloudiness, particulate matter, or discoloration is observed.
• Inject subcutaneously into the abdomen or front of the thigh. The back of the upper arm can be used as an injection site if administered by a health care provider or caregiver.
• If a dose is missed, it should be administered as soon as remembered and resume monthly dosing from the date of the most recent dose.

Storage requirements:

• Refrigerate at 2C to 8C (36F to 46F) in the original carton.
• After removing from refrigerator, can store at room temperature between 15C and 30C (59F and 86F) in the original carton for up to 6 weeks; discard if not used within 6 weeks.
• Do not freeze. Do not expose to heat. Protect from light.

General:

• Hypersensitivity reactions (including symptoms of bronchospasm, diffuse erythema, facial swelling, urticaria, chills, myalgias) requiring medical treatment have occurred.

Patient advice:

• Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
• If signs or symptoms of hypersensitivity reactions occur, discontinue this drug, and immediately seek medical help.
• Using lipid-regulating agents does not reduce the importance of adhering to a low-fat diet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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