Livtencity Dosage

Generic name: MARIBAVIR 200mg
Dosage form: tablet, coated
Drug class: Miscellaneous antivirals

Medically reviewed by Drugs.com. Last updated on Oct 25, 2022.

Recommended Dosage

The recommended dosage in adults and pediatric patients (12 years of age and older and weighing at least 35 kg) is 400 mg (two 200 mg tablets) taken orally twice daily with or without food [see Use in Specific Populations (8.4), Clinical Pharmacology (12.3) and Clinical Studies (14)].

Dosage Adjustment When Co-administered with Anticonvulsants

If LIVTENCITY is co-administered with carbamazepine, increase the dosage of LIVTENCITY to 800 mg (four 200 mg tablets) twice daily [see Drug Interactions (7.3)].

If LIVTENCITY is co-administered with phenytoin or phenobarbital, increase the dosage of LIVTENCITY to 1,200 mg (six 200 mg tablets) twice daily [see Drug Interactions (7.3)].

Administration

The immediate-release tablets can be taken as whole, dispersed or crushed tablets by mouth, or as dispersed tablets through a nasogastric or orogastric tube (French size 10 or larger). The suspension may be prepared ahead of time and stored at room temperature for up to 8 hours.

Administration of Dispersed Tablets or Crushed Tablets by Mouth

Place the appropriate number of tablets for the prescribed dose into a suitable container. If desired, the tablets may be crushed. Add the appropriate volume of drinking water (other liquids have not been tested) to make a suspension (see Table 1 below).

Table 1: Number of Tablets and Volume of Drinking Water Needed to Make a Suspension for Administration of Dispersed or Crushed Tablets by Mouth
Recommended Dosage	Number of 200 mg Tablets	Volume of Drinking Water
400 mg	Two	30 mL
800 mg	Four	60 mL
1,200 mg	Six	90 mL

Swirl the container gently to keep the particles from settling, and administer the suspension before it settles. The mixture will have a bitter taste.
Rinse the container with 15 mL of drinking water and administer the rinse water.
Repeat Step 3. Visually confirm that no particles are left in the container. If particles remain, repeat Step 3.

Administration of Dispersed Tablets through a Nasogastric (NG) or Orogastric (OG) Tube

Remove the cap (if applicable) and plunger out of a 50 or 60 mL catheter-tip compatible syringe or equivalent. Add two tablets into the syringe body and place the plunger back in the syringe. Only two tablets can be administered via NG or OG tube at a time.
Draw 30 mL of drinking water (other liquids have not been tested) into the syringe and hold the syringe with the tip pointing upward. Pull the plunger further to a higher volume position to have some air space in the syringe. Place the cap back on the syringe (if applicable). Shake the syringe well (careful not to spill the contents) for about 30 to 45 seconds or until the tablets are completely dispersed.
Once the tablets are completely dispersed in the syringe, remove the cap from the syringe again (if applicable) and attach the syringe to the NG or OG tube and administer the dispersion before it settles.
Draw 15 mL of water using the same syringe and flush through the same NG or OG tube.
Repeat Step 4 and make sure no particles are left in the syringe by visual inspection. If particles remain, repeat Step 4.
For doses of 800 mg (four 200 mg tablets) and 1,200 mg (six 200 mg tablets) [see Dosage and Administration (2.2)], repeat Steps 1-5 until prescribed dose is reached. The same syringe, NG or OG tube can be used.