Skip to Content

Lanadelumab Dosage

Medically reviewed by Drugs.com. Last updated on Sep 17, 2020.

Applies to the following strengths: 300 mg/2 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hereditary Angioedema

Initial dose: 300 mg subcutaneously once every 2 weeks; a 4-week dosing interval may be considered if the patient is well-controlled (e.g., attack free) for more than 6 months.

Use: To prevent attacks of hereditary angioedema (HAE).

Usual Pediatric Dose for Hereditary Angioedema

12 Years or Older:
Initial dose: 300 mg subcutaneously once every 2 weeks; a 4-week dosing interval may be considered if the patient is well-controlled (e.g., attack free) for more than 6 months.

Use: To prevent attacks of hereditary angioedema (HAE).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-The patient or caregiver should be trained on administration of this drug by a healthcare professional.
-Inject the complete prescribed dose subcutaneously into the abdomen, thigh, or upper arm.
-In clinical studies, most patients self-administered this drug over 10 to 60 seconds.

Storage requirements:
-Refrigerate at 36F to 46F (2C to 8C). Do not freeze.
-Protect from light.
-Administer within 2 hours of preparing the dosing syringe.
-After the dosing syringe is prepared, it can be refrigerated at 36F to 46F (2C to 8C) and must be used within 8 hours.
-Discard any unused portions of drug remaining in the vial and syringe.

Reconstitution/preparation techniques:
-Avoid vigorous agitation of the vial.
-Remove from the refrigerator 15 minutes before injecting.
-Withdraw the prescribed dose from the vial using an 18-gauge needle.
-Change the needle on the syringe to a 27-gauge, 0.5-inch needle or other needle suitable for subcutaneous injection.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions