Lanadelumab Dosage

Medically reviewed by Drugs.com. Last updated on Sep 17, 2020.

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Usual Adult Dose for Hereditary Angioedema

Initial dose: 300 mg subcutaneously once every 2 weeks; a 4-week dosing interval may be considered if the patient is well-controlled (e.g., attack free) for more than 6 months.

Use: To prevent attacks of hereditary angioedema (HAE).

Usual Pediatric Dose for Hereditary Angioedema

12 Years or Older:
Initial dose: 300 mg subcutaneously once every 2 weeks; a 4-week dosing interval may be considered if the patient is well-controlled (e.g., attack free) for more than 6 months.

Use: To prevent attacks of hereditary angioedema (HAE).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-The patient or caregiver should be trained on administration of this drug by a healthcare professional.
-Inject the complete prescribed dose subcutaneously into the abdomen, thigh, or upper arm.
-In clinical studies, most patients self-administered this drug over 10 to 60 seconds.

Storage requirements:
-Refrigerate at 36F to 46F (2C to 8C). Do not freeze.
-Protect from light.
-Administer within 2 hours of preparing the dosing syringe.
-After the dosing syringe is prepared, it can be refrigerated at 36F to 46F (2C to 8C) and must be used within 8 hours.
-Discard any unused portions of drug remaining in the vial and syringe.

Reconstitution/preparation techniques:
-Avoid vigorous agitation of the vial.
-Remove from the refrigerator 15 minutes before injecting.
-Withdraw the prescribed dose from the vial using an 18-gauge needle.
-Change the needle on the syringe to a 27-gauge, 0.5-inch needle or other needle suitable for subcutaneous injection.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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