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Evithrom Dosage

Generic name: HUMAN THROMBIN 1000[iU] in 1mL
Dosage form: topical liquid
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by Last updated on Nov 28, 2022.

For topical use only. DO NOT INJECT.


The amount of EVITHROM® required depends upon the area of tissue to be treated and the method of application. As an approximate guide, volumes up to 10 mL were used in clinical studies where EVITHROM® was applied in conjunction with Absorbable Gelatin Sponge, USP.


Thaw prior to use

Thaw EVITHROM® in one of the following ways:

  • 2°C to 8°C (refrigerator): vials thaw within 1 day; or
  • 20°C to 25°C (room temperature): vials thaw within 1 hour; or
  • 37°C for 2 ml and 5 ml vials only: vials thaw within 10 minutes. Do not exceed 37°C and do not leave vials at 37°C for longer than 10 minutes.

Once thawed

Remove the flip-off plastic cap from the vial to expose the rubber stopper.

If using EVITHROM® alone: withdraw the thrombin solution from the glass vial with a sterile needle and syringe.

If using EVITHROM® in conjunction with an absorbable gelatin sponge: remove the rubber stopper (by removing the metal pull tab) and transfer thrombin solution into a sterile container large enough to immerse sponge


DO NOT INJECT. Apply only on the surface of bleeding tissue.


  • Sponge target surface (do not wipe) or suction free of blood before application.
  • Flood the surface with EVITHROM® using a sterile syringe and small gauge needle.
  • After treatment, avoid sponging the clot to assure that it remains securely in place.

EVITHROM® in conjunction with absorbable gelatin sponge, USP

  • Using aseptic techniques, immerse gelatin sponge of desired shape into the sterile container with the EVITHROM® solution.
  • Vigorously knead the sponge with moistened gloved fingers until all air is expelled and it can return to its original size and shape.
  • Hold the saturated sponge in place with gauze or cotton pledget using moderate pressure until hemostasis is achieved.

Vials are for single use only. Discard unused contents.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.