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Botulism Immune Globulin Dosage

Medically reviewed on March 13, 2018.

Applies to the following strengths: 100 mg

Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Botulism

Under 1 year old: 1 mL/kg (50 mg/kg) IV
-Begin infusion slowly, at 0.5 mL/kg/hour (25 mg/kg/hour); if no untoward reactions after 15 minutes, may increase rate to 1 mL/kg/hour (50 mg/kg/hour) - DO NOT EXCEED THIS RATE OF ADMINISTRATION
-Monitor the patient closely after each rate change.

Use(s): Treatment of infant botulism caused by toxin type A or B in patients below 1 year of age.

Renal Dose Adjustments

Use with caution.
-Administer at minimum concentration and rate of infusion.

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients older than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Do not pre-dilute before infusion.
-Begin infusion within 2 hours after reconstitution is complete, and conclude within 4 hours of reconstitution, unless infusion is temporarily interrupted for an adverse reaction.
-Administer using low volume tubing and a constant infusion pump through a separate infusion line.
-If a separate line is not possible, may piggyback into a pre-existing line containing either sodium chloride injection USP or one of the following dextrose solutions (with or without sodium chloride added): 2.5, 5, 10, or 20% dextrose in water.
-If a pre-existing line is used, do not dilute to more than 1:2 with any of the above-named solutions.
-Use an in-line or syringe-tip sterile, disposable 18 micrometer filter for administration.
-Do not exceed the recommended dose, concentration and rate of infusion.
-Begin infusion slowly, at 0.5 mL/kg/hour (25 mg/kg/hour); if no untoward reactions after 15 minutes, may increase rate to 1 mL/kg/hour (50 mg/kg/hour) - DO NOT EXCEED THIS RATE OF ADMINISTRATION

Reconstitution/preparation techniques:
-This product is preservative free; after reconstitution, enter only once for the purpose of administration.
-Reconstitute with 2 mL sterile water for injection (to make a 50 mg/mL solution).
-Rotate container gently to wet all the powder; allow approximately 30 minutes for all the powder to dissolve.
-DO NOT SHAKE VIAL; foaming will occur.

Monitoring:
-Monitor vital signs continuously during infusion.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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