Skip to Content

Betaine Dosage

Medically reviewed by Drugs.com. Last updated on Nov 11, 2020.

Applies to the following strengths: hydrochloride 100%; 100%

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hyperhomocysteinemia

Initial dose: 3 grams orally twice a day
-Increase the dose gradually until plasma total homocysteine is undetectable or only present in small amounts
Maximum dose: Some patients have required 20 grams/day

Comments:
-One in vitro pharmacokinetic/pharmacodynamic study showed minimal benefit from more than twice daily dosing and 150 mg/kg/day betaine.
-An initial plasma homocysteine response takes several days; steady state is reached within a month.

Uses: To decreases elevated blood homocysteine levels in the treatment of homocystinuria from:
-Cystathionine beta-synthase (CBS) deficiency
-5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency
or
-Cobalamin cofactor metabolism (cbl) defect

Usual Pediatric Dose for Hyperhomocysteinemia

3 years and older:
Initial dose: 3 grams orally twice a day
-Increase the dose gradually until plasma total homocysteine is undetectable or only present in small amounts

Under 3 years:
Initial dose: 100 mg/kg/day divided into 2 daily doses
-Increase weekly by 50 mg/kg increments until plasma total homocysteine is undetectable or only present in small amounts


Comments:
-Some patients have required 20 grams/day.
-One in vitro pharmacokinetic/pharmacodynamic study showed minimal benefit from more than twice daily dosing and 150 mg/kg/day betaine.
-An initial plasma homocysteine response takes several days; steady state is reached within a month.

Uses: To decreases elevated blood homocysteine levels in the treatment of homocystinuria from:
-Cystathionine beta-synthase (CBS) deficiency
-5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency
or
-Cobalamin cofactor metabolism (cbl) defect

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:
-Store at room temperature; protect from moisture.

Reconstitution/preparation techniques:
-Shake bottle lightly before removing cap.
-Measure the dose using the provided scoop; 1 level scoop (1.7 mL) equals 1 gram betaine.
-Mix with 4 to 6 ounces water, juice, milk, or formula until completely dissolved, or mix with food, ingest immediately.
-Replace cap tightly.

Monitoring:
-Monitor plasma homocysteine concentrations for patient response to therapy.
-Monitor plasma methionine in cystathionine beta-synthase (CBS) deficiency.

More about betaine

Consumer resources

Other brands
Cystadane

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.