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Baloxavir Marboxil Dosage

Medically reviewed by Drugs.com. Last updated on Nov 14, 2018.

Applies to the following strengths: 20 mg; 40 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Influenza

40 to less than 80 kg: 40 mg orally once as a single dose
At least 80 kg: 80 mg orally once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic for no more than 48 hours who are otherwise healthy or at high risk of developing influenza-related complications

Usual Pediatric Dose for Influenza

12 years or older:
-Weight 40 to less than 80 kg: 40 mg orally once as a single dose
-Weight at least 80 kg: 80 mg orally once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic for no more than 48 hours who are otherwise healthy or at high risk of developing influenza-related complications

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
History of hypersensitivity to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Comments:
-This drug is highly bound to serum proteins; significant removal by dialysis is unlikely.

Other Comments

Administration advice:
-Start therapy within 48 hours of onset of influenza symptoms.
-Administer with or without food; avoid coadministration with dairy products, calcium-fortified beverages, polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., calcium, iron, magnesium, selenium, zinc).
-For the 40 mg dose: Administer two 20 mg tablets at the same time.
-For the 80 mg dose: Administer two 40 mg tablets at the same time.

Storage requirements:
-Store in blister package at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).

General:
-Limitations of use: As influenza viruses change over time, factors (e.g., virus type/subtype, emergence of resistance, changes in viral virulence) could reduce clinical benefit of antiviral drugs; available drug susceptibility patterns for circulating influenza virus strains should be considered when deciding whether to use this drug.
-This drug is not a substitute for annual influenza vaccination as recommended by the US CDC Advisory Committee on Immunization Practices.
-Serious allergic reactions have included anaphylaxis, angioedema, urticaria, and erythema multiforme.

Patient advice:
-Read the US FDA-approved patient labeling (Patient Information).
-Follow the healthcare provider's dosing recommendations for a single, 1-time dose.
-Seek immediate medical attention if an allergic-like reaction occurs/is suspected.
-Consult healthcare provider before receiving a live attenuated influenza vaccine after taking this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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