Aqneursa Dosage

Important Recommendation Prior to AQNEURSA Treatment Initiation

For females of reproductive potential, verify that the patient is not pregnant.

Recommended Dosage

The recommended dosage of AQNEURSA is based on the patient’s actual body weight (kg) to be administered orally up to three times daily. See Table 1.

AQNEURSA can be taken with or without food.

For 2 gram levacetylleucine doses, prepare two AQNEURSA packets individually.

One AQNEURSA packet contains 1 gram levacetylleucine.

Missed Dose

If a dose of AQNEURSA is missed, skip the missed dose and take the next dose at the scheduled time. Do not take 2 doses at the same time to make up for a missed dose.

Preparation and Administration Instructions

Oral Administration

For oral administration, administer AQNEURSA as follows:

1. Obtain the required number of AQNEURSA packets for the prescribed dose (one or two packets).

2. Open and empty the entire contents of one AQNEURSA packet into a container with 40 mL of water, orange juice, or almond milk. Do not use hot liquid.

3. Stir to form a suspension.

4. Swallow the suspension immediately (within 30 minutes).

5. For doses requiring two AQNEURSA packets, repeat steps 2 to 4.

6. Discard unused AQNEURSA suspension if not administered within 30 minutes.

Use of Gastrostomy Tube (G-Tube) for Feeding Tube Administration

For patients who have a G-tube (French size 18 or larger) in place, administer AQNEURSA as follows:

1. Prepare AQNEURSA suspension immediately before administration via gastrostomy tube.

2. Obtain the required number of AQNEURSA packets for the prescribed dose (one or two packets).

3. Open and empty the entire contents of one AQNEURSA packet into a container with 40 mL of water ONLY. Do not use hot liquid.

4. Stir to form a suspension.

5. Draw up the suspension into a catheter tip syringe.

6. Administer the suspension immediately through the G-tube.

7. Flush any residual suspension in the catheter tip syringe with an additional 20 mL of water.

8. Flush the G-tube again, as needed, until no residual suspension is left in the syringe or feeding tube.

9. For doses requiring two AQNEURSA packets, repeat steps 3 to 8.

10. Discard unused AQNEURSA suspension if not administered immediately.