Antivenin (Micrurus Fulvius) Dosage

Usual Adult Dose for Venomous Snake Bite

Average dose: 3 to 5 vials

• Dose depends on response to treatment

Comments:

• Each reconstituted vial can neutralize approximately 2 mg Micrurus fulvius venom (approximately 250 mouse LD 50 [lethal dose]).

Use: Only for treatment of envenomation by North American coral snake (Micrurus, including eastern and Texas varieties)

Usual Pediatric Dose for Venomous Snake Bite

Adolescents: Average dose: to 5 vials

• Dose depends on response to treatment

Small children: Dose may be decreased, depending on response to treatment

Comments:

• Each reconstituted vial can neutralize approximately 2 mg Micrurus fulvius venom (approximately 250 mouse LD 50 [lethal dose]).

Use: Only for treatment of envenomation by North American coral snake (Micrurus, including eastern and Texas varieties)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Do not administer prophylactically to asymptomatic patients
• Hypersensitivity to horse serum, unless benefits outweigh risks and anaphylaxis management is readily available

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For intravenous administration only.
• The manufacturer product information should be consulted for detailed administration instructions.

Storage requirements:

• Refrigerate; do not freeze

Reconstitution/preparation techniques:

• Reconstitute each vial with 10 mL sterile water for injection
• Do not shake
• Swirl for 1 minute every 5 minutes until complete dissolution
• Complete reconstitution takes at least 30 minutes
• Use within 4 hours of reconstitution.

IV compatibility:

• Sodium chloride

General:

• Determine if the patient is hypersensitive to horse serum.

Patient advice:

• Patients should contact a healthcare provider immediately if signs of delayed allergic reaction or serum sickness appear within 2 weeks of hospital discharge.
• Signs include rash, itching, joint pain, fever, lymphadenopathy, and malaise.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer