Acetaminophen / Dextromethorphan / Diphenhydramine / Pseudoephedrine Dosage

Usual Adult Dose for Cold Symptoms

Acetaminophen/dextromethorphan/diphenhydramine/PSE varying strength oral kit:
Day time capsules (without diphenhydramine): 2 capsules every 6 hours during waking hours as needed.
Night time tablets (without dextromethorphan): 2 capsules every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 capsules/day of day and night capsules combined.

Usual Adult Dose for Influenza

Acetaminophen/dextromethorphan/diphenhydramine/PSE varying strength oral kit:
Day time capsules (without diphenhydramine): 2 capsules every 6 hours during waking hours as needed.
Night time tablets (without dextromethorphan): 2 capsules every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 capsules/day of day and night capsules combined.

Usual Pediatric Dose for Cold Symptoms

Acetaminophen/dextromethorphan/diphenhydramine/PSE varying strength oral kit:
12 yrs or older: Day time capsules (without diphenhydramine): 2 capsules every 6 hours during waking hours as needed.
Night time tablets (without dextromethorphan): 2 capsules every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 capsules/day of day and night capsules combined.

Usual Pediatric Dose for Influenza

Acetaminophen/dextromethorphan/diphenhydramine/PSE varying strength oral kit:
12 yrs or older: Day time capsules (without diphenhydramine): 2 capsules every 6 hours during waking hours as needed.
Night time tablets (without dextromethorphan): 2 capsules every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 capsules/day of day and night capsules combined.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

Dialysis

Data not available