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Tham (tromethamine) Disease Interactions

There are 4 disease interactions with Tham (tromethamine):

Major

Tromethamine (applies to Tham) altered CO2 tension/ventilation

Major Potential Hazard, High plausibility. Applicable conditions: Acidosis

The use of tromethamine is contraindicated in patients with chronic respiratory acidosis. Tromethamine decreases carbon dioxide tension resulting in depressed ventilation.

References

  1. "Product Information. Tham (tromethamine)." Abbott Pharmaceutical, Abbott Park, IL.
Major

Tromethamine (applies to Tham) renal dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Hyperkalemia

The use of tromethamine is contraindicated in patients with severe renal impairment (anuria, uremia) and should be administered with caution in patients with renal dysfunction. Tromethamine may accumulate in patients with renal impairment as it is not appreciably metabolized and is primarily eliminated by the kidney. Hyperkalemia may result due to tromethamine use in patients with compromised renal function. Clinical monitoring of renal function and electrolyte levels is recommended.

References

  1. "Product Information. Tham (tromethamine)." Abbott Pharmaceutical, Abbott Park, IL.
Moderate

Alkalinizing agents (applies to Tham) acid/base balance

Moderate Potential Hazard, High plausibility. Applicable conditions: Alkalosis, Arrhythmias, Seizures

Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.

References

  1. "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical, Abbott Park, IL.
  2. "Product Information. Tham (tromethamine)." Abbott Pharmaceutical, Abbott Park, IL.
  3. "Product Information. Urocit (potassium citrate)." Mission Pharmacal Company, San Antonio, TX.
Moderate

Tromethamine (applies to Tham) glucose alterations

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

Dose-related changes in blood glucose concentrations resulting in hypoglycemia have occurred during administration of tromethamine. Rapid infusion of tromethamine has also resulted in prolonged hypoglycemia. Therapy with tromethamine should be administered cautiously in patients with diabetes and temporary dosage modification of antihyperglycemic agents may be necessary.

References

  1. "Product Information. Tham (tromethamine)." Abbott Pharmaceutical, Abbott Park, IL.

Tham (tromethamine) drug interactions

There are 33 drug interactions with Tham (tromethamine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.