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Thiamine Disease Interactions

There are 2 disease interactions with thiamine:

Moderate

Thiamine (applies to thiamine) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Thiamine products contain aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Caution is advised when using in patients with renal disease and in premature neonates as their kidneys are immature.

Moderate

Vitamin B complex (applies to thiamine) malabsorption

Moderate Potential Hazard, High plausibility. Applicable conditions: Malabsorption Syndrome, Alcoholism, Cirrhosis

The B vitamins are readily absorbed in the GI tract following oral administration. However, GI absorption may be decreased in patients with malabsorption syndromes and other conditions. For example, the absorption of thiamine and pyridoxine may commonly be decreased in alcoholics and in patients with cirrhosis. Likewise, riboflavin absorption may be impaired in patients with hepatitis, cirrhosis, or biliary obstruction. When malabsorption of these vitamins is suspected, parenteral administration may be appropriate.

References

  1. "Product Information. Quinine (riboflavin)." Watson/Rugby Laboratories Inc, Norcross, GA.
  2. "Product Information. Nestrex (pyridoxine)." Fielding Company, Maryland Heights, MO.
  3. "Product Information. Vitamin B1 (thiamine)." Dixon-Shane Inc, Philadelphia, PA.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer