Mintezol Disease Interactions
There are 3 disease interactions with Mintezol (thiabendazole).
Anthelmintics (applies to Mintezol) supportive therapy
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dehydration, Malnourished, Anemia
Patients with anemia, dehydration, or malnutrition should receive supportive therapy for these complicating conditions prior to initiation of certain anthelmintic therapy.
References (3)
- (2001) "Product Information. Mintezol (thiabendazole)." Merck & Co., Inc
- (2001) "Product Information. Antiminth (pyrantel)." Pfizer U.S. Pharmaceuticals Group
- (2001) "Product Information. Piperazine (piperazine)." Global Pharmaceutical Corporation
Thiabendazole (applies to Mintezol) liver disease
Moderate Potential Hazard, Moderate plausibility.
Thiabendazole is extensively metabolized by the liver. Therapy with thiabendazole should be administered cautiously and with careful monitoring in patients with liver disease.
References (5)
- Roy MA, Nugent FW, Aretz HT (1989) "Micronodular cirrhosis after thiabendazole." Dig Dis Sci, 34, p. 938-41
- Fink AI, MacKay CJ, Cutler SS (1979) "Sicca complex and cholangiostatic jaundice in two members of a family probably caused by thiabendazole." Ophthalmology, 86, p. 1892-6
- Tocco DJ, Rosenblum C, Martin CM, Robinson HJ (1966) "Absorption, metabolism, and excretion of thiabendazole in man and laboratory animals." Toxicol Appl Pharmacol, 9, p. 31-9
- (2001) "Product Information. Mintezol (thiabendazole)." Merck & Co., Inc
- Bion E, Pariente EA, Maitre F (1995) "Severe cholestasis and sicca syndrome after thiabendazole." J Hepatol, 23, p. 762-3
Thiabendazole (applies to Mintezol) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Thiabendazole is excreted in the urine (90%). Therapy with thiabendazole should be administered cautiously and with careful monitoring in patients with renal dysfunction.
References (5)
- Bauer LA, Raisys VA, Watts MT, Ballinger J (1982) "The pharmacokinetics of thiabendazole and its metabolites in an anephric patient undergoing hemodialysis and hemoperfusion." J Clin Pharmacol, 22, p. 276-80
- Schumaker JD, Band JD, Lensmeyer GL, Craig WA (1978) "Thiabendazole treatment of severe strongyloidiasis in a hemodialyzed patient." Ann Intern Med, 89, p. 644-5
- Leapman SB, Rosenberg JB, Filo RS, Smith EJ (1980) "Strongyloides stercoralis in chronic renal failure: safe therapy with thiabendazole." South Med J, 73, p. 1400-2
- Tocco DJ, Rosenblum C, Martin CM, Robinson HJ (1966) "Absorption, metabolism, and excretion of thiabendazole in man and laboratory animals." Toxicol Appl Pharmacol, 9, p. 31-9
- (2001) "Product Information. Mintezol (thiabendazole)." Merck & Co., Inc
Switch to consumer interaction data
Mintezol drug interactions
There are 56 drug interactions with Mintezol (thiabendazole).
Mintezol alcohol/food interactions
There are 2 alcohol/food interactions with Mintezol (thiabendazole).
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More about Mintezol (thiabendazole)
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- Drug class: anthelmintics
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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