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Tetrabenazine Disease Interactions

There are 7 disease interactions with tetrabenazine:

Major

Tetrabenazine (Includes Tetrabenazine) ↔ Cardiac Arrhythmias

Severe Potential Hazard, Moderate plausibility

Applies to: Arrhythmias, Long QT Syndrome

Tetrabenazine can cause an increase in the corrected QT interval. QT prolongation can lead to the development of ventricular arrhythmias. The use of tetrabenazine should be avoided in patients with congenital long QT syndrome and in patients with a history of arrhythmias.

Major

Tetrabenazine (Includes Tetrabenazine) ↔ Depression

Severe Potential Hazard, Moderate plausibility

Applies to: Depression

The use of tetrabenazine is contraindicated in patients with untreated or uncontrolled depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and behavior.

Major

Tetrabenazine (Includes Tetrabenazine) ↔ Hepatic Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of tetrabenazine is contraindicated in patients with hepatic impairment. The safety and efficacy of exposure to the drug and other metabolites are unknown and it is not possible to adjust the dosage in hepatic impairment to ensure safe use.

Major

Tetrabenazine (Includes Tetrabenazine) ↔ Huntington's Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Huntington Disease

Patients with Huntington disease are prone to depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and should be used with caution in patients with Huntington's disease. The benefits and risks of treatment should be considered before starting therapy, and patients should be under close observation for emergence or worsening of depression symptoms. The family and caregivers should also be informed of this risk and should be instructed to report any changes in behavior or any concerns to the treating physician.

Moderate

Tetrabenazine (Includes Tetrabenazine) ↔ Dysphagia

Moderate Potential Hazard, Moderate plausibility

Applies to: Dysphagia, Huntington Disease

Tetrabenazine reduces dopaminergic transmission and can be associated with esophageal dysmotility and dysphagia. Caution should be exercised when used in patients with conditions that predispose to dysphagia. Special caution is advised in patients with Huntington's disease as dysphagia is a common symptom and it could lead to aspiration pneumonia.

Moderate

Tetrabenazine (Includes Tetrabenazine) ↔ Hyperprolactinemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Hyperprolactinemia, Osteoporosis, Breast Cancer

Tetrabenazine can elevate serum prolactin concentrations. This should be considered when therapy will be prescribed in patients with previously detected breast cancer. Additionally, chronic increase in serum prolactin has been associated with low levels of estrogen and increase risk of osteoporosis. If there is suspicion of hyperprolactinemia, appropriate laboratory testing is advised and treatment discontinuation should be considered.

Moderate

Tetrabenazine (Includes Tetrabenazine) ↔ Hypotension

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypotension, Syncope

Tetrabenazine can induce postural dizziness and syncope and should be used with caution in patients who are vulnerable to hypotension.

tetrabenazine drug Interactions

There are 891 drug interactions with tetrabenazine

tetrabenazine alcohol/food Interactions

There is 1 alcohol/food interaction with tetrabenazine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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