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Flumadine (rimantadine) Disease Interactions

There are 3 disease interactions with Flumadine (rimantadine):

Moderate

Rimantadine (Includes Flumadine) ↔ Liver Disease

Moderate Potential Hazard, High plausibility

Applies to: Liver Disease

Rimantadine is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with liver disease. One-half the usual dosage is recommended for patients with severe hepatic dysfunction.

References

  1. Wills RJ, Belshe R, Tomlinsin D, De Grazia F, Lin A, Wells S, Milazzo J, Berry C "Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease." Clin Pharmacol Ther 42 (1987): 449-54
  2. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
Moderate

Rimantadine (Includes Flumadine) ↔ Renal Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Rimantadine and its metabolites are excreted by the kidney. Patients with renal impairment may be at greater risk for adverse effects from rimantadine due to decreased drug clearance. Therapy with rimantadine should be administered cautiously in patients with renal impairment. One-half the usual dosage is recommended for patients with severe renal dysfunction (CrCl <= 10 mL/min).

References

  1. Tominack RL, Wills RJ, Gustavson LE, Hayden FG "Multiple-dose pharmacokinetics of rimantadine in elderly adults." Antimicrob Agents Chemother 32 (1988): 1813-9
  2. Capparelli EV, Stevens RC, Chow MS, Izard M, Wills RJ "Rimantadine pharmacokinetics in healthy subjects and patients with end-stage renal failure." Clin Pharmacol Ther 43 (1988): 536-41
  3. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
View all 4 references
Moderate

Rimantadine (Includes Flumadine) ↔ Seizure Disorders

Moderate Potential Hazard, Low plausibility

Applies to: Seizures

Seizures have been reported in a few patients with a history of seizure disorders who were not receiving anticonvulsant medication while taking rimantadine. Therapy with rimantadine should be administered cautiously in patients with epilepsy or predisposed to seizures.

References

  1. "Product Information. Flumadine (rimantadine)." Forest Pharmaceuticals, St. Louis, MO.
  2. Bentley DW, Karki SD, Betts RF "Rimantadine and seizures." Ann Intern Med 110 (1989): 323-4
  3. Millet VM, Dreisbach M, Bryson YJ "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother 21 (1982): 1-4

Flumadine (rimantadine) drug Interactions

There are 22 drug interactions with Flumadine (rimantadine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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