Prussian blue Disease Interactions

Prussian blue insoluble is not absorbed through the intact gastrointestinal wall and its clearance depends on the gastrointestinal tract transit time. Prussian blue can decrease gastrointestinal motility and slow the transit time of the agent in the gastrointestinal tract and increase the radiation absorbed. Also, the use of prussian blue can cause constipation. Care is recommended in patients with disorders associated with decreased gastrointestinal motility as these patients are at higher risk and should be carefully monitored.

The use of prussian blue may decrease electrolytes found in the gastrointestinal tract. Hypokalemia has been reported with the use of prussian blue, and this might be more pronounced in patients with preexisting cardiac arrhythmias or electrolyte imbalances. It is recommended to closely monitor these patient's serum electrolytes levels during therapy with this agent.

Prussian blue insoluble binds cesium and thallium isotopes in the gastrointestinal tract after these isotopes are ingested or excreted in the bile by the liver. Prussian blue does not rely on hepatic metabolism. Its clearance from the body depends on the gastrointestinal tract transit time. Prussian blue may be less effective in patients with liver disease due to decreased excretion of cesium and thallium in the bile. Care should be exercised when using this agent in patients with hepatic impairment.