Pralidoxime Disease Interactions
There are 2 disease interactions with pralidoxime.
Pralidoxime (applies to pralidoxime) myasthenic crisis
Major Potential Hazard, High plausibility. Applicable conditions: Myasthenia Gravis
Pralidoxime reactivates cholinesterase activity resulting in reduced levels of acetylcholine and increased neuromuscular junction activity. Treatment of organophosphate poisoning in patients myasthenia gravis with pralidoxime can precipitate a myasthenic crisis.
Pralidoxime (applies to pralidoxime) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Pralidoxime is eliminated by the kidney. Approximately 80% to 90% of pralidoxime is excreted in the urine as unchanged drug. The serum concentration of pralidoxime is increased in patients with renal impairment. Therapy with pralidoxime should be administered cautiously and dosages reduced in patients with compromised renal function. Clinical monitoring of renal function and muscular activity is recommended.
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Pralidoxime drug interactions
There are 3 drug interactions with pralidoxime.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Tropicacyl
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Mydriacyl
Mydriacyl is used for pupillary dilation, refraction, assessment
Talvey
Talvey is used to treat relapsed or refractory multiple myeloma. Includes Talvey side effects ...
DuoDote
DuoDote is used for nerve agent poisoning, organophosphate poisoning
Tropicamide ophthalmic
Tropicamide ophthalmic is used for organophosphate poisoning, pupillary dilation, refraction, assessment
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.