Vitamin K1 (phytonadione) Disease Interactions
There is 1 disease interaction with Vitamin K1 (phytonadione):
Phytonadione (vit. K) (applies to Vitamin K1) hepatobiliary dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Biliary Obstruction
Phytonadione is fat soluble and requires bile for adequate intestinal absorption. Biliary dysfunction decreases the absorption of phytonadione. Phytonadione is metabolized by the liver and excreted in bile and urine. Hepatic and/or biliary impairment can alter the metabolic and therapeutic activity of phytonadione. Phytonadione will not correct hypoprothrombinemia due to hepatocellular dysfunction or damage and administration of excessive phytonadione may worsen hepatic function.
- Barkhan P, Shearer MJ "Metabolism of vitamin K1 (phylloquinone) in man." Proc R Soc Med 70 (1977): 93-6
- Shearer MJ, McBurney A, Barkhan P "Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man." Vitam Horm 32 (1974): 513-42
- "Product Information. Mephyton (phytonadione)." Merck & Co, Inc, West Point, PA.
- "Product Information. Vitamin K Injection (phytonadione)." Abbott Pharmaceutical, Abbott Park, IL.
- Ballard HS, Marcus AJ "Decompensated portal cirrhosis. Effects of large doses of phytonadione." Arch Intern Med 117 (1966): 182-6
Vitamin K1 (phytonadione) drug interactions
There are 9 drug interactions with Vitamin K1 (phytonadione)
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- Drug class: anticoagulant reversal agents
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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