Mifepristone Disease Interactions
There are 6 disease interactions with mifepristone:
- Organ transplant
- Vaginal bleeding
- Cardiovascular disease
- Hepatic impairment
- Long QT
- Renal impairment
Mifepristone (Includes mifepristone) ↔ organ transplant
Severe Potential Hazard, High plausibility. Applies to: Organ Transplant
Mifepristone is contraindicated in patients with serious medical conditions, such as patients requiring treatment with systemic corticosteroids for immunosuppression after organ transplantation. Mifepristone antagonizes the effects of glucocorticoids.
Mifepristone (Includes mifepristone) ↔ vaginal bleeding
Severe Potential Hazard, Moderate plausibility. Applies to: Endometrial Dysplasia, Abnormal Uterine Bleeding, Bleeding Associated with Coagulation Defect
Mifepristone is contraindicated in women with unexplained vaginal bleeding, and women with endometrial hyperplasia with atypia or endometrial carcinoma, as it promotes endometrial proliferation that may result in endometrium thickening, cystic dilatation of endometrial glands, and vaginal bleeding. It should also be used with caution in women with hemorrhagic disorders or those receiving anticoagulation therapy.
Mifepristone (Includes mifepristone) ↔ cardiovascular disease
Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease, Heart Disease
Mifepristone does not reduce serum cortisol levels, and elevated cortisol levels might activate mineralocorticoid receptors which are expressed in cardiac tissue. Caution should be used in patients with underlying heart conditions, including heart failure and coronary vascular disease.
Mifepristone (Includes mifepristone) ↔ hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
There is limited information on the safety of mifepristone in patients with mild to moderate hepatic impairment, hence the manufacturers recommend that the maximum dose should not exceed 600 mg per day. The use of mifepristone is not recommended in patients with severe hepatic disease as the pharmacokinetics in these patients have not been studied.
Mifepristone (Includes mifepristone) ↔ long QT
Moderate Potential Hazard, Moderate plausibility. Applies to: Long QT Syndrome
Mifepristone prolongs the QTc interval in a dose-related manner. There is little or no experience with high exposure, concomitant dosing with other QT- prolonging drugs, or potassium channel variants resulting in long QT interval. Caution and monitoring is advised if used in patients with long QT. To minimize risk, the lowest effective dose should always be used.
Mifepristone (Includes mifepristone) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
No change in the initial dose of mifepristone is needed for renal impairment; but the manufacturers recommend that the maximum dose should not exceed 600 mg per day in these patients.
Mifepristone drug interactions
There are 778 drug interactions with mifepristone
Mifepristone alcohol/food interactions
There is 1 alcohol/food interaction with mifepristone
More about mifepristone
- Mifepristone Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 1 Review
- Drug class: progesterone receptor modulators
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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