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M-M-R II Disease Interactions

There are 2 disease interactions with M-M-R II (measles virus vaccine / mumps virus vaccine / rubella virus vaccine).

Major

MMR (applies to M-M-R II) immunodeficiency

Major Potential Hazard, High plausibility.

In general, the use of measles, mumps, and rubella vaccine or any single component is contraindicated in patients with primary or acquired immunodeficiency. Since these vaccines contain live attenuated viruses, the absence of immune competence may potentiate the replication of vaccine virus, increase adverse host reactions, and compromise serum antibody response. Likewise, the vaccine should not be administered to anyone with a family history of congenital or hereditary immunodeficiency until the individual's immune status can be assessed and is determined to be adequate. In the case of HIV infection, patients without overt clinical manifestations suggesting severe immunodeficiency should be vaccinated because measles can be particularly severe and potentially fatal in the presence of HIV. However, immunization may be less effective in these patients, and they should be monitored for vaccine-preventable diseases.

References

  1. "Product Information. Mumpsvax (mumps virus vaccine)." Merck & Company Inc (2022):
  2. "Product Information. Meruvax II (rubella virus vaccine)." Merck & Company Inc (2022):
  3. "Product Information. Attenuvax (measles virus vaccine)." Merck & Company Inc (2022):
  4. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics (1997):
View all 4 references
Major

Vaccination (applies to M-M-R II) infections

Major Potential Hazard, High plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral, Fever, Infection - Bacterial/Fungal/Protozoal/Viral, Fever, Infection - Bacterial/Fungal/Protozoal/Viral, Fever

Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.

References

  1. "Product Information. Typhim VI (typhoid vaccine, inactivated)." Apothecon Inc (2022):
  2. "Product Information. Varivax (varicella virus vaccine)." Merck & Company Inc (2022):
  3. "Product Information. Pneumovax 23 (pneumococcal 23-polyvalent vaccine)." Merck & Company Inc (2022):
  4. "Product Information. Mumpsvax (mumps virus vaccine)." Merck & Company Inc (2022):
  5. "Product Information. Meruvax II (rubella virus vaccine)." Merck & Company Inc (2022):
  6. "Product Information. Attenuvax (measles virus vaccine)." Merck & Company Inc (2022):
  7. "Product Information. Orimune (poliovirus vaccine, live, trivalent)." Lederle Laboratories (2022):
  8. "Product Information. YF-Vax (yellow fever vaccine)." sanofi pasteur (2001):
  9. "Product Information. Omnihib (haemophilus b conjugate vaccine)." SmithKline Beecham, Philadelphia, PA.
  10. "Product Information. Menomune-A/C/Y/W-135 (meningococcal polysaccharide vaccine)." Connaught, Swiftwater, PA.
  11. "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc (2001):
  12. American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases." Grove Village, IL: American Academy of Pediatrics (1997):
  13. "Product Information. Cholera vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  14. "Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
  15. "Product Information. Engerix-B (hepatitis B adult vaccine)." Apothecon Inc (2022):
  16. "Product Information. Zostavax (zoster vaccine live)." Merck & Company Inc (2006):
  17. "Product Information. Gardasil (human papillomavirus vaccine)." Merck & Company Inc (2006):
  18. "Product Information. Gardasil 9 (human papillomavirus vaccine)." Merck & Company Inc (2016):
View all 18 references

M-M-R II drug interactions

There are 273 drug interactions with M-M-R II (measles virus vaccine / mumps virus vaccine / rubella virus vaccine).


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.