Idursulfase Disease Interactions
There is 1 disease interaction with idursulfase.
Idursulfase (applies to idursulfase) cardiac/pulmonary impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease, Fever, Fluid Retention
Patients with compromised respiratory function or acute respiratory disease may be at risk of serious acute exacerbation of their respiratory compromise due to hypersensitivity reactions during idursulfase therapy and require additional monitoring. Patients with compromised respiratory function or acute febrile or respiratory illness at the time of idursulfase infusion may be at higher risk of life-threatening complications from hypersensitivity reactions. Careful consideration should be given to the patient's clinical status before idursulfase administration and delaying the idursulfase infusion should be considered.
Caution is recommended when administering idursulfase to patients susceptible to fluid overload, or patients with acute underlying respiratory illness or compromised cardiac and/or respiratory function for whom fluid restriction is indicated; these patients may be at risk of serious exacerbation of their cardiac or respiratory status during infusions. Appropriate medical support and monitoring measures should be readily available during idursulfase infusion, and some patients may require prolonged observation times that should be based on the needs of each patient.
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- During pregnancy
- Drug class: lysosomal enzymes
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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