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Glycerol phenylbutyrate Disease Interactions

There are 4 disease interactions with glycerol phenylbutyrate:

Moderate

Glycerol Phenylbutyrate (Includes Glycerol phenylbutyrate) ↔ Fat Malabsorption

Moderate Potential Hazard, Moderate plausibility

Applies to: Malabsorption Syndrome

Pancreatic enzymes hydrolyze glycerol phenylbutyrate in the small intestine. Intestinal disease resulting in fat malabsorption may result in reduced digestion of glycerol phenylbutyrate. It is recommended to monitor the ammonia levels closely in patients with pancreatic insufficiency or intestinal malabsorption.

Moderate

Glycerol Phenylbutyrate (Includes Glycerol phenylbutyrate) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Patients with hepatic impairment may have higher plasma phenylacetate (PAA) and phenylacetate to phenylacetylglutamine (PAGN) ratio due to a reduced conversion capability of PAA to PAGN in the liver. Patients with moderate to severe hepatic impairment may require lower dosages of glycerol phenylbutyrate than normal to control the patient's ammonia levels. Caution is recommended in patients with hepatic impairment as no studies have been conducted.

Moderate

Glycerol Phenylbutyrate (Includes Glycerol phenylbutyrate) ↔ Neuropathy

Moderate Potential Hazard, Moderate plausibility

Applies to: Peripheral Neuropathy

The major metabolite of glycerol phenylbutyrate, PAA, is associated with neurotoxicity. Cases of exacerbation of preexisting neuropathy have been documented in patients using this agent. It is recommended to exercise caution when using glycerol phenylbutyrate in patients with neuropathy.

Moderate

Glycerol Phenylbutyrate (Includes Glycerol phenylbutyrate) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The efficacy and safety of glycerol phenylbutyrate in patients with renal impairment are unknown. It is recommended to monitor ammonia levels closely when using this agent in patients with impaired renal function.

glycerol phenylbutyrate drug Interactions

There are 483 drug interactions with glycerol phenylbutyrate

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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