Glycerol phenylbutyrate Disease Interactions
There are 4 disease interactions with glycerol phenylbutyrate.
Glycerol phenylbutyrate (applies to glycerol phenylbutyrate) fat malabsorption
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Malabsorption Syndrome
Pancreatic enzymes hydrolyze glycerol phenylbutyrate in the small intestine. Intestinal disease resulting in fat malabsorption may result in reduced digestion of glycerol phenylbutyrate. It is recommended to monitor the ammonia levels closely in patients with pancreatic insufficiency or intestinal malabsorption.
Glycerol phenylbutyrate (applies to glycerol phenylbutyrate) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Patients with hepatic impairment may have higher plasma phenylacetate (PAA) and phenylacetate to phenylacetylglutamine (PAGN) ratio due to a reduced conversion capability of PAA to PAGN in the liver. Patients with moderate to severe hepatic impairment may require lower dosages of glycerol phenylbutyrate than normal to control the patient's ammonia levels. Caution is recommended in patients with hepatic impairment as no studies have been conducted.
Glycerol phenylbutyrate (applies to glycerol phenylbutyrate) neuropathy
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Peripheral Neuropathy
The major metabolite of glycerol phenylbutyrate, PAA, is associated with neurotoxicity. Cases of exacerbation of preexisting neuropathy have been documented in patients using this agent. It is recommended to exercise caution when using glycerol phenylbutyrate in patients with neuropathy.
Glycerol phenylbutyrate (applies to glycerol phenylbutyrate) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The efficacy and safety of glycerol phenylbutyrate in patients with renal impairment are unknown. It is recommended to monitor ammonia levels closely when using this agent in patients with impaired renal function.
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Glycerol phenylbutyrate drug interactions
There are 288 drug interactions with glycerol phenylbutyrate.
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- Drug class: urea cycle disorder agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Ravicti
Ravicti (glycerol phenylbutyrate) is used to treat urea cycle disorders. Includes Ravicti side ...
Amvuttra
Amvuttra is used to treat polyneuropathy associated with hereditary transthyretin-mediated ...
Sodium phenylbutyrate
Sodium phenylbutyrate systemic is used for urea cycle disorders
Further information
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