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Glycerol phenylbutyrate Side Effects

In Summary

Commonly reported side effects of glycerol phenylbutyrate include: dizziness, fatigue, headache, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to glycerol phenylbutyrate: oral solution

In addition to its needed effects, some unwanted effects may be caused by glycerol phenylbutyrate. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking glycerol phenylbutyrate:

More common:
  • Continuing nausea or vomiting
  • increase in the frequency of seizures
  • loss of appetite
  • swelling of the face
  • tiredness and weakness

Minor Side Effects

Some of the side effects that can occur with glycerol phenylbutyrate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bloated or full feeling
  • diarrhea
  • excess air or gas in the stomach or intestines
  • headache
  • nausea
  • passing gas
  • rash
  • upper abdominal or stomach pain
  • vomiting
Less common:
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort or upset

For Healthcare Professionals

Applies to glycerol phenylbutyrate: oral liquid

General

The most frequently reported side effects included diarrhea, flatulence, and headache.[Ref]

Nervous system

Very common (10% or more): Headache (14%), dizziness[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (16%), flatulence (14%), upper abdominal pain (pediatric patients), nausea , vomiting
Common (1% to 10%): Abdominal pain (adults) dyspepsia[Ref]

Metabolic

Very Common (10% or more): Decreased appetite, hyperammonemia[Ref]

Other

Common (1% to 10%): Fatigue[Ref]

Dermatologic

Very common (10% or more): Rash (pediatric patients)[Ref]

References

1. "Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc, South San Francisco, CA.

Not all side effects for glycerol phenylbutyrate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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