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Gvoke Disease Interactions

There are 4 disease interactions with Gvoke (glucagon).

Major

Glucagon (applies to Gvoke) insulinoma

Major Potential Hazard, High plausibility.

The use of glucagon is contraindicated in patients with insulinoma or glucagonoma as it may cause secondary hypoglycemia. Test patients suspected of having glucagonoma for blood levels of glucagon prior to treatment, and monitor for changes in blood glucose levels during treatment. If a patient develops symptoms of hypoglycemia after a dose of glucagon, administer glucose orally or intravenously.

References (1)
  1. (2001) "Product Information. Glucagon (glucagon)." Lilly, Eli and Company
Major

Glucagon (applies to Gvoke) pheochromocytoma

Major Potential Hazard, High plausibility.

The use of glucagon is contraindicated in patients with pheochromocytoma because glucagon may stimulate the release of catecholamines from the tumor, which may result in a sudden and marked increase in blood pressure.

References (1)
  1. (2001) "Product Information. Glucagon (glucagon)." Lilly, Eli and Company
Moderate

Glucagon (applies to Gvoke) cardiac disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Glucagon for injection may increase myocardial oxygen demand, blood pressure, and pulse rate which may be life-threatening in patients with cardiac disease. Cardiac monitoring is recommended in patients with cardiac disease during glucagon treatment, and an increase in blood pressure and pulse rate may require therapy.

References (1)
  1. (2001) "Product Information. Glucagon (glucagon)." Lilly, Eli and Company
Moderate

Glucagon (applies to Gvoke) glycogen depletion

Moderate Potential Hazard, High plausibility. Applicable conditions: Malnourished, Adrenal Insufficiency, Panhypopituitarism

Glucagon reverses hypoglycemia via mobilization of hepatic glycogen. It is not useful for treating hypoglycemic patients who are glycogen-depleted, a condition that can occur in starvation, adrenal insufficiency, or chronic hypoglycemia. Glucose administration should be considered in such cases.

References (1)
  1. (2001) "Product Information. Glucagon (glucagon)." Lilly, Eli and Company

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Gvoke drug interactions

There are 70 drug interactions with Gvoke (glucagon).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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