Givinostat Disease Interactions
There are 2 disease interactions with givinostat.
Givinostat (applies to givinostat) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The pharmacokinetics and safety of givinostat have not been studied in patients with hepatic impairment and the impact on systemic exposure cannot be excluded.
Givinostat (applies to givinostat) QTc prolongation
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias, Electrolyte Abnormalities, Ischemic Heart Disease
Treatment with givinostat may prolong QTc interval. Use should be avoided in patients who are at increased risk for ventricular arrhythmias, congenital long QT syndrome, coronary artery disease, electrolyte disturbance, and in patients who are taking concomitant medications that cause QT prolongation.
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Givinostat drug interactions
There are 532 drug interactions with givinostat.
Givinostat alcohol/food interactions
There is 1 alcohol/food interaction with givinostat.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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