Givinostat Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 10, 2024.

Applies to givinostat: oral suspension.

Side effects include:

Most common adverse reactions (≥10%): diarrhea, abdominal pain, thrombocytopenia, nausea/vomiting, hypertriglyceridemia, pyrexia.

For healthcare professionals

Applies to givinostat: oral suspension.

General adverse events

The most common side effects were abdominal pain, diarrhea, hypertriglyceridemia, nausea or vomiting, pyrexia, and thrombocytopenia.^[Ref]

Cardiovascular

• Frequency not reported: QTc prolongation

Dermatologic

• Common (1% to 10%): Rash

Endocrine

• Common (1% to 10%): Hypothyroidism, increased thyroid stimulating hormone

Gastrointestinal

• Very common (10% or more): Abdominal pain (34%), diarrhea (37%), nausea/vomiting (32%)
• Common (1% to 10%): Constipation

Abdominal pain included abdominal pain and upper abdominal pain.

Diarrhea included diarrhea and soft feces.

Hematologic

• Very common (10% or more): Thrombocytopenia (33%)

Thrombocytopenia included a decreased platelet count and thrombocytopenia.

Metabolic

• Very common (10% or more): Hypertriglyceridemia (23%)
• Common (1% to 10%): Decreased appetite

Hypertriglyceridemia included hypertriglyceridemia and increased blood triglycerides.

Musculoskeletal

• Common (1% to 10%): Arthralgia, myalgia

Other

• Very common (10% or more): Pyrexia (13%)
• Common (1% to 10%): Fatigue

See also:

Further information

Givinostat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer