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Rukobia (fostemsavir) Disease Interactions

There are 2 disease interactions with Rukobia (fostemsavir):


Fostemsavir (Includes Rukobia) ↔ hepatitis B

Moderate Potential Hazard, Moderate plausibility. Applies to: Infectious Hepatitis

Fostemsavir may cause elevations in hepatic transaminases in patients co-infected with hepatitis B or C. It is recommended to monitor liver function in patients with hepatitis B or C co-infection. Particular attention should be practiced in initiating or maintaining effective hepatitis B therapy when starting fostemsavir treatment in patients co-infected with hepatitis B.


Fostemsavir (Includes Rukobia) ↔ QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applies to: Heart Disease

Fostemsavir has been shown to significantly prolong the QTc interval of the electrocardiogram with higher than recommended dosages. Fostemsavir should be used with caution in patients with a history of QTc interval prolongation, when co-administered with a drug with a known risk of Torsade de Pointes, or in patients with relevant preexisting cardiac disease.

Rukobia (fostemsavir) drug interactions

There are 338 drug interactions with Rukobia (fostemsavir)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.