Rukobia Disease Interactions
There are 2 disease interactions with Rukobia (fostemsavir).
Fostemsavir (applies to Rukobia) hepatitis B
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infectious Hepatitis
Fostemsavir may cause elevations in hepatic transaminases in patients co-infected with hepatitis B or C. It is recommended to monitor liver function in patients with hepatitis B or C co-infection. Particular attention should be practiced in initiating or maintaining effective hepatitis B therapy when starting fostemsavir treatment in patients co-infected with hepatitis B.
Fostemsavir (applies to Rukobia) QT prolongation
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease
Fostemsavir has been shown to significantly prolong the QTc interval of the electrocardiogram with higher than recommended dosages. Fostemsavir should be used with caution in patients with a history of QTc interval prolongation, when co-administered with a drug with a known risk of Torsade de Pointes, or in patients with relevant preexisting cardiac disease.
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Rukobia drug interactions
There are 378 drug interactions with Rukobia (fostemsavir).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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