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Follicle stimulating hormone/ganirelix Disease Interactions

There are 5 disease interactions with follicle stimulating hormone / ganirelix.

Major

Follicle stimulating hormone (applies to follicle stimulating hormone/ganirelix) adrenal dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Adrenal Insufficiency, Hyperadrenocorticism

The use of follicle stimulating hormone (FSH) is contraindicated in patients with uncontrolled adrenal dysfunction. Uncontrolled adrenal dysfunction may involve the pituitary gland and be associated with a tumor or other dysfunction. Administration of FSH may exacerbate the condition.

References (4)
  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. (2002) "Product Information. Follistim (follicle stimulating hormone)." Organon
  3. (2002) "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc
  4. (2003) "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc
Major

Follicle stimulating hormone (applies to follicle stimulating hormone/ganirelix) thyroid dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypothyroidism, Hyperthyroidism

The use of follicle stimulating hormone (FSH) is contraindicated in patients with uncontrolled thyroid dysfunction. FSH is composed of both an alpha and beta subunit. The amino acid sequence of the alpha subunit of FSH is identical to that of TSH. Therefore, FSH may have weak TSH receptor- binding and activation.

References (4)
  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. (2002) "Product Information. Follistim (follicle stimulating hormone)." Organon
  3. (2002) "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc
  4. (2003) "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc
Major

Follicle stimulating hormone (applies to follicle stimulating hormone/ganirelix) tumors

Major Potential Hazard, High plausibility. Applicable conditions: Neoplasia -- Estrogen Dependent

The use of follicle stimulating hormone is contraindicated in patients with sex hormone-dependent tumors of the reproductive tract and accessory organs (ovary, breast, uterus) and in patients with pituitary tumors. FSH is required for normal sex hormone production, which may be detrimental in these patients. Patients in later reproductive life have a greater predisposition to endometrial carcinoma.

References (4)
  1. "Product Information. Fertinex (urofollitropin)." Serono Laboratories Inc
  2. (2002) "Product Information. Follistim (follicle stimulating hormone)." Organon
  3. (2002) "Product Information. Gonal-F (follicle stimulating hormone)." Serono Laboratories Inc
  4. (2003) "Product Information. Bravelle (urofollitropin)." Ferring Pharmaceuticals Inc
Major

Ganirelix (applies to follicle stimulating hormone/ganirelix) severe allergies

Major Potential Hazard, Moderate plausibility.

Treatment with ganirelix is not advised in women with severe allergic conditions.

References (1)
  1. (2001) "Product Information. Antagon (ganirelix)." Organon
Moderate

Ganirelix (applies to follicle stimulating hormone/ganirelix) renal/hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease, Renal Dysfunction

The pharmacokinetics of ganirelix acetate injection have not been determined in special populations such as renally impaired and hepatically impaired patients. Caution is advised.

References (1)
  1. (2001) "Product Information. Antagon (ganirelix)." Organon

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Follicle stimulating hormone/ganirelix drug interactions

There are 7 drug interactions with follicle stimulating hormone / ganirelix.

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More about follicle stimulating hormone / ganirelix

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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