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Fluor-Op Disease Interactions

There are 2 disease interactions with Fluor-Op (fluorometholone ophthalmic).

Major

Ophthalmic corticosteroids (applies to Fluor-Op) ocular infections

Major Potential Hazard, High plausibility.

The use of ophthalmic corticosteroids is contraindicated in most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella; fungal diseases of ocular structures; mycobacterial infections, including tuberculosis, of the eye; and any acute, purulent, untreated ocular infections. Corticosteroids may decrease host resistance to infectious agents, thus prolonging the course and/or exacerbating the severity of the infection while encouraging the development of new or secondary infection. In addition, administration of ophthalmic corticosteroids in severe ocular disease, especially acute herpes simplex keratitis, may lead to excessive corneal and scleral thinning, increasing the risk for perforation. In less serious ocular infections, therapy with ophthalmic corticosteroids may be administered but only with caution and accompanied by appropriate antimicrobial agents. Besides compromising host immune response, corticosteroids may also mask the symptoms of infection, thus hindering the recognition of potential ineffectiveness of the antibiotic therapy. If infection does not improve or becomes worse during administration of an ophthalmic corticosteroid, the drug should be discontinued and other appropriate therapy initiated.

References

  1. "Product Information. Vexol (rimexolone ophthalmic)." Alcon Laboratories Inc PROD (2001):
  2. "Product Information. Lotemax (loteprednol ophthalmic)." Bausch and Lomb PROD (2001):
  3. "Product Information. Pred Forte (prednisolone ophthalmic)." Allergan Inc PROD (2001):
  4. "Product Information. Decadron Ocumeter (dexamethasone ophthalmic)." Merck & Co., Inc PROD (2001):
  5. "Product Information. FML S.O.P. (fluorometholone ophthalmic)." Allergan Inc
  6. "Product Information. HMS (medrysone ophthalmic)." Allergan Inc PROD (2001):
View all 6 references
Major

Ophthalmic corticosteroids (applies to Fluor-Op) ocular toxicities

Major Potential Hazard, High plausibility. Applicable conditions: Cataracts, Glaucoma/Intraocular Hypertension

Prolonged use of corticosteroids may cause posterior subcapsular cataracts and elevated intraocular pressure, the latter of which may lead to glaucoma and/or damage to the optic nerves. Therapy with ophthalmic corticosteroids should be administered cautiously in patients with a history of cataracts, glaucoma, or increased intraocular pressure. If these agents are used for more than 10 days, the manufacturers recommend that intraocular pressure be routinely monitored, including in children. The equatorial and posterior subcapsular portions of the lens should be examined for changes.

References

  1. Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
  2. Godel V, Regenbogen L, Stein R "On the mechanism of corticosteroid-induced ocular hypertension." Ann Ophthalmol 10 (1978): 191-6
  3. Francois J "Corticosteroid glaucoma." Ann Ophthalmol 9 (1977): 1075-80
  4. Kitazawa Y "Increased intraocular pressure induced by corticosteroids." Am J Ophthalmol 82 (1976): 492-5
  5. Butcher JM, Austin M, McGalliard J, Bourke RD "Bilateral cataracts and glaucoma induced by long term use of steroid eye drops." BMJ 309 (1994): 43
  6. "Product Information. Vexol (rimexolone ophthalmic)." Alcon Laboratories Inc PROD (2001):
  7. Leibowitz HM, Bartlett JD, Rich R, Mcquirter H, Stewart R, Assil K "Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids." Arch Ophthalmol 114 (1996): 933-7
  8. Foster CS, Alter G, Debarge LR, Raizman MB, Crabb JL, Santos CI, Feiler LS, Friedlaender MH "Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis." Am J Ophthalmol 122 (1996): 171-82
  9. "Product Information. Lotemax (loteprednol ophthalmic)." Bausch and Lomb PROD (2001):
  10. "Product Information. Pred Forte (prednisolone ophthalmic)." Allergan Inc PROD (2001):
  11. "Product Information. Decadron Ocumeter (dexamethasone ophthalmic)." Merck & Co., Inc PROD (2001):
  12. "Product Information. FML S.O.P. (fluorometholone ophthalmic)." Allergan Inc
  13. "Product Information. HMS (medrysone ophthalmic)." Allergan Inc PROD (2001):
View all 13 references

Fluor-Op drug interactions

There are 41 drug interactions with Fluor-Op (fluorometholone ophthalmic).


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.