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Dimercaprol Disease Interactions

There are 2 disease interactions with dimercaprol:

Major

Dimercaprol (Includes dimercaprol) ↔ hepatic dysfunction

Severe Potential Hazard, High plausibility. Applies to: Liver Disease

The use of dimercaprol is contraindicated in patients with impaired hepatic function, except for arsenic- associated jaundice. Dimercaprol, not complexed to heavy metals, is metabolized by the liver to inactive forms in patients with normal hepatic function. Hepatic impairment decreases the metabolism of dimercaprol and can result in elimination of potentially nephrotoxic dimercaprol as well as increased CNS toxicity and hypertension.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.
Major

Dimercaprol (Includes dimercaprol) ↔ renal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction

Dimercaprol is primarily eliminated by the kidney complexed with a heavy metal (lead, arsenic, mercury, gold). Dimercaprol and heavy metals are nephrotoxic and dissociate at an acid pH. Urinary alkalinization during dimercaprol therapy is necessary. The serum concentration of dimercaprol is elevated in patients with oliguria and CNS toxicity and hypertension are possible. Dimercaprol should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy. Therapy with dimercaprol should be administered very cautiously and dosages reduced in patients with oliguria. Close clinical monitoring of urine pH and renal function is necessary.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.

Dimercaprol drug interactions

There are 35 drug interactions with dimercaprol

Dimercaprol alcohol/food interactions

There is 1 alcohol/food interaction with dimercaprol

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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