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Dimercaprol Disease Interactions

There are 5 disease interactions with dimercaprol:

Major

Dimercaprol (applies to dimercaprol) hepatic dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Liver Disease

The use of dimercaprol is contraindicated in patients with impaired hepatic function, except for arsenic- associated jaundice. Dimercaprol, not complexed to heavy metals, is metabolized by the liver to inactive forms in patients with normal hepatic function. Hepatic impairment decreases the metabolism of dimercaprol and can result in elimination of potentially nephrotoxic dimercaprol as well as increased CNS toxicity and hypertension.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.
Major

Dimercaprol (applies to dimercaprol) renal dysfunction

Major Potential Hazard, High plausibility.

Dimercaprol is primarily eliminated by the kidney complexed with a heavy metal (lead, arsenic, mercury, gold). Dimercaprol and heavy metals are nephrotoxic and dissociate at an acid pH. Urinary alkalinization during dimercaprol therapy is necessary. The serum concentration of dimercaprol is elevated in patients with oliguria and CNS toxicity and hypertension are possible. Dimercaprol should be discontinued or used only with extreme caution if acute renal insufficiency develops during therapy. Therapy with dimercaprol should be administered very cautiously and dosages reduced in patients with oliguria. Close clinical monitoring of urine pH and renal function is necessary.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.
Moderate

Dimercaprol (applies to dimercaprol) peanut allergy

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Allergies

Dimercaprol ampules are formulated with peanut oil. Peanut oil may cause allergic reactions in some individuals. Physicians should use caution in prescribing dimercaprol ampules for peanut-sensitive patients. Medication and equipment necessary to treat allergic reactions should be available if the product is administered to peanut-allergic patients.

Moderate

Dimercaprol (applies to dimercaprol) hemolysis/G6PD deficiency

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Dimercaprol-associated hemolysis has been reported in patients with glucose-6-phosphate dehydrogenase deficiency. Therapy with dimercaprol should be administered with caution in patients with G6PD deficiency. Clinical monitoring of erythropoietic function including hemolysis is recommended.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.
Moderate

Dimercaprol (applies to dimercaprol) hypertension

Moderate Potential Hazard, High plausibility.

Dose-related increase in systolic and diastolic blood pressure, with or without accompanying tachycardia, is the most frequently reported adverse effect of dimercaprol therapy. Blood pressure may rise 15 to 30 minutes following injection and usually returns to normal within 2 hours. Therapy with dimercaprol should be administered cautiously in patients with hypertension. Clinical monitoring of blood pressure is recommended.

References

  1. "Product Information. BAL in Oil (dimercaprol)." Becton Dickinson, Franklin Lakes, NJ.

Dimercaprol drug interactions

There are 23 drug interactions with dimercaprol

Dimercaprol alcohol/food interactions

There are 2 alcohol/food interactions with dimercaprol

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.