Difelikefalin Disease Interactions
There is 1 disease interaction with difelikefalin.
Moderate
Difelikefalin (applies to difelikefalin) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The use of difelikefalin in patients with severe hepatic impairment has not been evaluated and is not recommended. A population pharmacokinetic analysis has shown that dosage adjustments are not needed in patients with mild to moderate hepatic impairment. The metabolism of this drug is unknown.
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Difelikefalin drug interactions
There are 255 drug interactions with difelikefalin.
Difelikefalin alcohol/food interactions
There is 1 alcohol/food interaction with difelikefalin.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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