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Difelikefalin Disease Interactions

There is 1 disease interaction with difelikefalin.

Moderate

Difelikefalin (applies to difelikefalin) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of difelikefalin in patients with severe hepatic impairment has not been evaluated and is not recommended. A population pharmacokinetic analysis has shown that dosage adjustments are not needed in patients with mild to moderate hepatic impairment. The metabolism of this drug is unknown.

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Difelikefalin drug interactions

There are 255 drug interactions with difelikefalin.

Difelikefalin alcohol/food interactions

There is 1 alcohol/food interaction with difelikefalin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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