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COVID-19 mRNA (Moderna) vaccine Disease Interactions

There are 3 disease interactions with COVID-19 mRNA (Moderna) vaccine.

Moderate

COVID-19 vaccine, mRNA (applies to COVID-19 mRNA (Moderna) vaccine) immunodeficiency

Moderate Potential Hazard, Moderate plausibility.

Immunocompromised individuals, including those receiving immunosuppressive therapy, may have a diminished immune response to the messenger RNA COVID-19 vaccine. The US CDC has published considerations related to COVID-19 vaccination for individuals who are moderately to severely immunocompromised (https://www.cdc.gov/covid/hcp/vaccine-considerations/).

Moderate

COVID-19 vaccine, mRNA (applies to COVID-19 mRNA (Moderna) vaccine) syncope

Moderate Potential Hazard, Moderate plausibility.

Syncope may occur in association with administration of injectable vaccines, including the messenger RNA COVID-19 vaccine. Procedures should be in place to avoid injury from fainting, especially for patients who have previously fainted in association with an injection.

Moderate

Vaccines (applies to COVID-19 mRNA (Moderna) vaccine) IM injection

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopathy, Thrombocytopenia, Coagulation Defect

In patients with thrombocytopenia or coagulation disorders, IM injections may produce bleeding and hematomas. Patients with a platelet count less than 50,000/mm3 are at an increased risk. Caution is advised if the vaccine (e.g., plague vaccine; hepatitis A and B vaccines; aluminum-adsorbed DTaP, DTP, DT, or Td) must be administered IM. The risk of bleeding may be minimized by vaccination immediately after the administration of replacement factor, use of a 23-gauge (or smaller) needle, and immediate application of direct pressure to the vaccination site for at least 2 minutes.

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COVID-19 mRNA (Moderna) vaccine drug interactions

There are 350 drug interactions with COVID-19 mRNA (Moderna) vaccine.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.